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The Contributions of Thrombospondin-1 to Epilepsy Formation

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Abstract

Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks. Abnormal synaptogenesis plays a vital role in the formation of overexcited networks. Recent evidence has confirmed that thrombospondin-1 (TSP-1), mainly secreted by astrocytes, is a critical cytokine that regulates synaptogenesis during epileptogenesis. Furthermore, numerous studies have reported that TSP-1 is also involved in other processes, such as angiogenesis, neuroinflammation, and regulation of Ca2+ homeostasis, which are closely associated with the occurrence and development of epilepsy. In this review, we summarize the potential contributions of TSP-1 to epilepsy development.

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Acknowledgements

This review was supported by the Natural Science Foundation of Shandong Province (ZR2021MH034 and ZR2022MH059) and the National Natural Science Foundation of China (81573412). We’d like to thank Editage for English language editing.

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  1. Yao Cheng and Yujie Zhai contributed equally to this review.

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  1. School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, 264003, China

    Yao Cheng, Yujie Zhai, Yi Yuan, Qiaoyun Wang, Shucui Li & Hongliu Sun

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Cheng, Y., Zhai, Y., Yuan, Y. et al. The Contributions of Thrombospondin-1 to Epilepsy Formation. Neurosci. Bull. (2024). https://doi.org/10.1007/s12264-024-01194-2

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