Progeria, or premature ageing, is a devastating condition caused by defects in the nuclear envelope and is associated with systemic inflammation. A study now shows in animal models that inhibiting necroptosis, and particularly activity of the RIPK1 kinase, reduces inflammation and results in a meaningful extension in lifespan1.
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J.S. is a consultant for a company developing RIPK1 inhibitors. P.W. has no competing interests to declare.
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Wang, P., Silke, J. RIPK1 and necroptosis role in premature ageing. Nat Cell Biol 26, 508–509 (2024). https://doi.org/10.1038/s41556-024-01390-2
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DOI: https://doi.org/10.1038/s41556-024-01390-2