SCHEDULED MAINTENANCE
Palladium-catalyzed alkynylation of allylic gem-difluorides†
Jun-hua
Li, 
a
Ming
Chen
*a
a
Ming
Chen
*a
Abstract
Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic gem-difluorides via C–F bond activation/transmetallation/β-C elimination or nucleophilic attack has been achieved. This innovative protocol showcases an extensive substrate range and operates efficiently under mild reaction conditions, resulting in high product yields and Z-selectivity. Particularly noteworthy is its exceptional tolerance towards a wide array of functional groups. This developed methodology provides effective and convenient routes to access a diverse array of essential fluorinated enynes, esters and amines.
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