Magnetostrictive-piezocatalytic CoFe2O4@UiO-66 nanohybrid and its potential for deep-seated tumor treatment

Qian Yu; Meiyu Li; Jiaojiao Zhang; Hong Liu; Long Zhang; Shun Li; Dengfeng Ge; Jianming Zhang

doi:10.1039/D4CC00885E

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Magnetostrictive-piezocatalytic CoFe₂O₄@UiO-66 nanohybrid and its potential for deep-seated tumor treatment†

Qian Yu,

*^a Meiyu Li,^a Jiaojiao Zhang,^b Hong Liu,^b Long Zhang,

^b Shun Li,

^b Dengfeng Ge*^c and Jianming Zhang

*^b

Author affiliations

* Corresponding authors

^a School of Life Sciences, Jiangsu University, 301 Xuefu Rd, Zhenjiang 212013, China
E-mail: qianyu@ujs.edu.cn

^b School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang 212013, China
E-mail: zhangjm@ujs.edu.cn

^c Shengli Oilfield Central Hospital, 31 Ji’nan Rd, Dongying, China
E-mail: gedengfeng@126.com

Abstract

Magnetostrictive CoFe₂O₄ (CFO) nanoparticles were encapsulated within a UiO-66 metal–organic-framework layer to form a CFO@UiO-66 nanohybrid. The deforming of CFO, in response to a high-frequency AC magnetic field, initiates the piezocatalytic property of UiO-66 to generate ˙OH radicals, which can kill cancer cells buried in thick tissues, showcasing bright potential for deep-seated tumor treatment.

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Article information

DOI: https://doi.org/10.1039/D4CC00885E
Article type: Communication
Submitted: 24 Feb 2024
Accepted: 26 Mar 2024
First published: 27 Mar 2024

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Chem. Commun., 2024,60, 4463-4466

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Magnetostrictive-piezocatalytic CoFe₂O₄@UiO-66 nanohybrid and its potential for deep-seated tumor treatment

Q. Yu, M. Li, J. Zhang, H. Liu, L. Zhang, S. Li, D. Ge and J. Zhang, Chem. Commun., 2024, 60, 4463 DOI: 10.1039/D4CC00885E

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