Nanopore sensitization based on a double loop hybridization chain reaction and G-quadruplex

Yanru Li; Chunmiao Yu; Yesheng Wang; Jin Yu; Huaning Wang; Bingling Li

doi:10.1039/D4CC00125G

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Nanopore sensitization based on a double loop hybridization chain reaction and G-quadruplex†

Yanru Li,^ab Chunmiao Yu,^ab Yesheng Wang,^ab Jin Yu,^ab Huaning Wang^ab and Bingling Li

*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China
E-mail: binglingli@ciac.ac.cn

^b School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui, China

Abstract

The widespread implementation of solid-state nanopores faces challenges such as lower resolution and increased electrical noise when compared to biological nanopores. Incorporating specific nucleic acid reactions can enhance resolution. In this study, we’ve developed a nucleic acid amplifier to enhance the sensitivity of solid-state nanopores, utilizing a G-rich sequence and hybridization chain reaction. This amplifier improves target concentration and volume amplification, showing promise in nanopore sensitivity tests.

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Article information

DOI: https://doi.org/10.1039/D4CC00125G
Article type: Communication
Submitted: 09 Jan 2024
Accepted: 26 Mar 2024
First published: 27 Mar 2024

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Chem. Commun., 2024,60, 4487-4490

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Nanopore sensitization based on a double loop hybridization chain reaction and G-quadruplex

Y. Li, C. Yu, Y. Wang, J. Yu, H. Wang and B. Li, Chem. Commun., 2024, 60, 4487 DOI: 10.1039/D4CC00125G

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Chemical Communications

Nanopore sensitization based on a double loop hybridization chain reaction and G-quadruplex†

Abstract

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Nanopore sensitization based on a double loop hybridization chain reaction and G-quadruplex

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