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Novel Chitosan Beeswax Matrix for Gastro-Retentive Delivery of Curcumin: A Promising Adjuvant Therapy for Helicobacter Infection

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Abstract

Purpose

The main purpose of this study is to introduce a new adjuvant treatment for H. pylori that aims to enhance therapy outcomes. The research question is how to create a controlled-release gastro-retentive floating system using a combination of chitosan (CS) and beeswax (BW) and to evaluate the release behavior of curcumin as an active ingredient.

Methods

In this study, a new formula combining CS and BW was developed through a hot melting process to create a controlled-release gastro-retentive floating system. Response surface methodology (RSM) was employed to determine the optimal conditions and concentrations of CS and BW to produce the desired floating system. Parameters such as mixing time, processing melting temperature, and concentration of BW were evaluated.

Results

The study found that the optimal parameters for the CS/BW formulation were determined as follows: a mixing time of 3 min, a processing melting temperature of 92.2 °C, and a BW concentration of 13.3% (w/w). Curcumin was incorporated into the optimal tablet, and its release behavior was evaluated. The results showed a full floating behavior of the tablet and a zero-order release behavior in acidic conditions.

Conclusions

The study successfully introduced a new adjuvant treatment for H. pylori that utilizes a controlled-release gastro-retentive floating system. The combination of CS and BW, along with the incorporation of curcumin, showed promising results in terms of floating behavior and release kinetics. This new treatment approach has the potential to enhance therapy outcomes for H. pylori infections.

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Data Availability

Data will be available from the corresponding author upon reasonable request.

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Acknowledgements

The authors are thankful for the Deanship of Scientific Research at University of Petra for funding this research.

Funding

The study was funded by a grant (4-2022) of the Deanship of Scientific Research from University of Petra (UOP), Amman, Jordan.

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Authors and Affiliations

  1. Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan

    Nisrein Jaber

  2. Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan

    Mayyas Al-Remawi

  3. Faculty of Arts and Sciences, University of Petra, Amman, Jordan

    Rami A. Abdel-Rahem

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  1. Nisrein Jaber
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  2. Mayyas Al-Remawi
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  3. Rami A. Abdel-Rahem
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The author confirms sole responsibility for the following: Al Remawi M: Study conception, design, and manuscript preparation. Jaber N and Abdel-Rahem R.: data collection, analysis and interpretation of results.

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Correspondence to Mayyas Al-Remawi.

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Jaber, N., Al-Remawi, M. & Abdel-Rahem, R. Novel Chitosan Beeswax Matrix for Gastro-Retentive Delivery of Curcumin: A Promising Adjuvant Therapy for Helicobacter Infection. J Pharm Innov 19, 16 (2024). https://doi.org/10.1007/s12247-024-09824-y

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