Bioactivity of cerium dioxide nanoparticles as a function of size and surface features

Veronika Sarnatskaya; Yuliia Shlapa; Denis Kolesnik; Olexandra Lykhova; Dmytro Klymchuk; Serhii Solopan; Svitlana Lyubchyk; Iuliia Golovynska; Junle Qu; Yurii Stepanov; Anatolii Belous

doi:10.1039/D3BM01900D

Bioactivity of cerium dioxide nanoparticles as a function of size and surface features

Veronika Sarnatskaya,*^a Yuliia Shlapa,

*^b Denis Kolesnik,^a Olexandra Lykhova,^a Dmytro Klymchuk,^c Serhii Solopan,^a Svitlana Lyubchyk,^de Iuliia Golovynska,

^f Junle Qu,

^de Yurii Stepanov

^a and Anatolii Belous

^b

Author affiliations

* Corresponding authors

^a R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, 45, Vasylkivska Str., Kyiv, Ukraine
E-mail: vsnikavera@gmail.com

^b V. I. Vernadsky Institute of General & Inorganic Chemistry of the NAS of Ukraine, 32/34, Palladina ave., Kyiv, Ukraine
E-mail: yuliashlapa@ukr.net

^c M.G. Kholodny Institute of Botany of the NAS of Ukraine, 2, Tereshchenkivska str., Kyiv, Ukraine

^d Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisboa, Portugal

^e Quinta de Torre, Campus de Caparica, 2829-516 Caparica, Portugal

^f Shenzhen Key Laboratory of Photonics and Biophotonics, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, P.R. China

Abstract

Nano-dispersed cerium dioxide is promising for use in medicine due to its unique physicochemical properties, including low toxicity, the safety of in vivo usage, active participation in different redox processes occurring in living cells, and its regenerative potential, manifested in the ability of CeO₂ to participate repeatedly in redox reactions. In this work, we examined the biological activity of cerium dioxide nanoparticles (CeO₂ NPs) synthesized by precipitation in mixed water/alcohol solutions at a constant pH of 9. This synthesis method allowed controlling the size and Ce³⁺/Ce⁴⁺ proportion on the surface of NPs, changing the synthesis conditions and obtaining highly stable suspensions of “naked” CeO₂ NPs. Changes in the surface properties upon contact of CeO₂ NPs with protein-rich media, e.g., bovine serum albumin and DMEM cell culture medium supplemented with 10% fetal bovine serum, the characteristics of nanoparticle uptake by mouse aortic endothelial cells and the antioxidant activity of the nanoparticles of different sizes were investigated by various state-of-the-art analytical methods.

Biomaterials Science

Bioactivity of cerium dioxide nanoparticles as a function of size and surface features

Abstract

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