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Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States

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Abstract

Background

How pediatric medulloblastoma patients fare in Lower Middle-Income Country (LMICs) in South America is not well understood. Correspondingly, the aim of this study was to summarize the pediatric neurosurgical experience of an institution in La Paz, and compare outcomes to that of a generalized High Income Country (HIC) United States (US) experience.

Methods

A retrospective review of all pediatric neurosurgical medulloblastoma patients at the Children’s Hospital of La Paz, Bolivia (Hospital del Niño “Dr. Ovidio Aliaga Uria”) between 2014 and 2023 was conducted and compared to a generalized US experience abstracted from the US National Cancer Database (NCDB) and National Inpatient Sample (NIS) databases. Categorical, continuous and survival data were statistically summarized and compared.

Results

A total of 24 pediatric medulloblastoma patients underwent neurosurgical treatment at the Hospital del Niño. In this La Paz cohort, there were 15 (63%) males and 9 (38%) females, with a mean age of 5.6 years old at diagnosis. The majority of patients underwent subtotal resection (STR, 79%), while the remaining patients underwent biopsy only. Ten (42%) patients expired during their hospitalization, and mean length of stay overall was 39 days. Only 8 (33%) patients received adjuvant treatment after surgery. Median overall survival from diagnosis in the La Paz cohort was 1.9 months. Compared to the US databases, the La Paz cohort experienced significantly more emergency room admissions for surgery, less gross total resection, more STR, more return to operating room for ventriculoperitoneal shunting, more bacteremia, more tracheostomy procedures, more percutaneous gastrostomy placements, longer lengths of stay, less adjuvant chemotherapy, less radiation therapy, shorter follow-up, and ultimately, significantly shorter overall survival (all P < 0.050).

Conclusions

Pediatric neurosurgical medulloblastoma outcomes at the Children’s Hospital of La Paz, Bolivia are significantly inferior to that of a generalized US experience. Future research is required to identify institution- and country-specific initiatives to improve discrepancies between institutions in LMICs in South America compared to HICs.

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No datasets were generated or analysed during the current study.

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Acknowledgements

We would like to thank the organizations of the AANS/CNS Pediatric Section, Mission Brain, and Solidarity Bridge, for their assistance in this effort.

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Authors and Affiliations

  1. Department of Neurological Surgery, Hospital del Niño “Dr. Ovidio Aliaga Uria”, La Paz, Bolivia

    Victor M. Lu, Jorge Daniel Brun & Jorge David Brun

  2. Department of Neurological Surgery, University of Miami, Jackson Memorial Hospital, Miami, FL, USA

    Victor M. Lu & Toba N. Niazi

  3. Department of Neurological Surgery, Nicklaus Children’s Hospital, Miami, FL, USA

    Victor M. Lu & Toba N. Niazi

Authors
  1. Victor M. Lu
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Contributions

V.M.L: conceptualization, data curation, writing—original draft preparation. All authors: writing—reviewing and editing, writing—final approval, supervision.

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Correspondence to Victor M. Lu.

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Lu, V.M., Brun, J.D., Niazi, T.N. et al. Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States. J Neurooncol (2024). https://doi.org/10.1007/s11060-024-04664-9

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