Abstract
Objective
Previous studies demonstrated a significant protective effect of elevated cerebrospinal fluid (CSF) sTREM2 levels on brain structure and cognitive decline. Nonetheless, the role of sTREM2 in the depression progression remains unclear. This study aimed to investigate the association between CSF sTREM2 levels and longitudinal trajectories of depression.
Methods
Data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study were used. CSF sTREM2 levels and depression were measured using an ELISA-based assay and the Geriatric Depression Scale (GDS-15), respectively. Linear mixed-effect models were employed to assess the relationships between CSF sTREM2 levels and GDS scores.
Results
A total of 1,017 participants were enrolled at baseline, with a mean follow-up time of 4.65 years. Baseline CSF sTREM2 levels were negatively correlated with GDS scores (β=−0.21, P=0.022) after adjustment for age, gender, race/ethnicity, education, APOE ε4 carrier status, TREM2 rare variant carrier status, marital status, smoking, and clinical cognitive status.
Conclusion
Our findings suggested that a higher level of CSF sTREM2 was associated with a lower risk of depression.
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Availability of data and material: Data used in this study are available through the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu).
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Acknowledgements
Data collection and sharing for this project was funded by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012).
Funding
Funding Statement: The study was supported by the Pearl River Scholar Program of Guangdong Province (Health Science Section, No: 0920220206).
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Conflict of Interest and Disclosure Statement/ All authors have no conflicts of interest.
Ethical standard statement: Ethical approval was given by the local ethical committees of all involved sites of ADNI, and the research was conducted following the Helsinki Declaration.
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How to cite this article: Y. Wang, M. Ye, Q. Ji, et al. Association between Cerebrospinal Fluid sTREM2 Levels and Depression: The Alzheimer’s Disease Neuroimaging Initiative Study. J Prev Alz Dis 2024; https://doi.org/10.14283/jpad.2024.70
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Wang, Y., Ye, M., Ji, Q. et al. Association between Cerebrospinal Fluid sTREM2 Levels and Depression: The Alzheimer’s Disease Neuroimaging Initiative Study. J Prev Alzheimers Dis (2024). https://doi.org/10.14283/jpad.2024.70
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DOI: https://doi.org/10.14283/jpad.2024.70