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Allium hooshidaryae (Alliaceae)-based green-synthesized Fe3O4@MoS2 core–shell nanoparticles coated with chitosan and investigating their biological properties

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Abstract

Fe3O4@MoS2 core–shell nanoparticles have a wide range of potential uses in the field of biomedicine, including drug delivery, target therapies, and NIR-stimulated tumor therapy. Whenever using the risk-free nanosystem, it is very important to manufacture and cover core–shell Fe3O4@MoS2 nanoparticles with a biodegradable substance. In the present research, Fe3O4@MoS2 core–shell nanoparticles were green synthesized by applying Allium hooshidaryae plant extracted as a reducing and stabilizing agent and then coated with chitosan. Synthesized nanoparticles were characterized by several structural and physical techniques, like scanning electron microscope (SEM), transmission electron microscope (TEM), vibrating-sample magnetometer (VSM), X-ray powder diffraction (XRD), and fourier-transform infrared spectroscopy (FTIR). The MTT test and an in vitro antimicrobial assay were used to examine the biological properties of the final nanoparticles. SEM and TEM results revealed uniform distribution of spherical Fe3O4 NPs with the average size of 35.7 nm. Furthermore, TEM image revealed that the mean diameter of Fe3O4@MoS2 core–shell NPs was approximately 52.7 nm that the Fe3O4 NPs were surrounded by MoS2 nanosheet layers. Chitosan-coated green-synthesized Fe3O4@MoS2 core–shell nanoparticles exhibited promising anti-cancer properties against the MCF-7 cell line with an IC50 value of ~ 50.83% reduction at 1000 μg/mL in cell viability as well as good antibacterial capabilities of MBC 500 µg/mL and MBC 250 µg/mL against Staphylococcus aureus and Pseudomonas aeruginosa, respectively. As a result, the synthesized nanoparticles have the potential to have useful benefits in future nanomedicine.

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Authors and Affiliations

  1. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

    Milad Abbasi & Ali Mohammad Amani

  2. Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Reza Kasaee

  3. Faculty of Architecture and Urbanism, UTE University, Calle Rumipamba S/N and Bourgeois, Quito, Ecuador

    Hesam Kamyab

  4. Department of Biomaterials, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, 600 077, India

    Hesam Kamyab

  5. Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia

    Hesam Kamyab & Irina Kirpichnikova

  6. Engineering Department, Razak Faculty of Technology & Informatics, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia

    Shreeshivadasan Chelliapan

  7. College of Pharmacy, University of Al-Ameed, Kerbala, 56001, Iraq

    Zainab Haider Mussa

  8. Department of Materials Science and Engineering, Shiraz University of Technology, Shiraz, Iran

    Sareh Mosleh-Shirazi

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  1. Milad Abbasi
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Contributions

Methodology, Data analysis, and Writing-original draft: Milad Abbasi. Data analysis, Investigation, and Reviewing and Editing: Seyed Reza Kasaee. Investigation, Reviewing, and Editing: Shreeshivadasan Chelliapan, Issa Farhan Deyab, and Fouad Fadhil Al-Qaim. Investigation, Writing, Reviewing and Editing, and Supervision: Ali Mohammad Amani, Sareh Mosleh-Shirazi, and Hesam Kamyab.

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Correspondence to Ali Mohammad Amani or Sareh Mosleh-Shirazi.

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Abbasi, M., Kasaee, S.R., Kamyab, H. et al. Allium hooshidaryae (Alliaceae)-based green-synthesized Fe3O4@MoS2 core–shell nanoparticles coated with chitosan and investigating their biological properties. Appl. Phys. A 130, 284 (2024). https://doi.org/10.1007/s00339-024-07440-8

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