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Fertility preservation in hematological cancer patients

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Abstract

Among adolescents and young adults, hematological malignancies are the most common malignancies. Although the survival rate of hematological malignancies in young patients has been dramatically improved, due to the continuous improvement and development of tumor diagnosis and treatment options, cytotoxic therapies can significantly reduce a patient’s reproductive capacity and cause irreversible infertility. The most two established solutions are embryo cryopreservation and oocyte cryopreservation which can be considered in single female. Sperm or testicular tissue cryopreservation in adult male are feasible approaches that must be considered before gonadotoxic therapy. A comprehensive consultation with reproductive specialists when once diagnosed is a significantly issue which would help those survivors who want to have children. In this article, we review germ cell toxicity, which happens during the treatment of hematological malignancies, and aims to propose safety, efficacy fertility preservation methods in younger patients with hematological malignancies.

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Funding

This work was supported by the Major Projects in Provincial and National Union Construction of Henan Medical Science and Technology Research Plan (SBGJ202001002).

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  1. Reproductive Medicine Center, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, China

    Dan Li, Yi-jun Zhao, Qian Wang, Man-wei Chu, Juan-ke Xie & Cui-lian Zhang

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Contributions

DL, Y-JZ, QW and M-WC contributed equally to the preparation of the first draft, revised the manuscript and share first authorship. C-LZ and J-KX contributed equally to the conception and design of the study. Each author listed on the manuscript has seen and approved the submission of this version of the manuscript and takes full responsibility for the manuscript.

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Correspondence to Cui-lian Zhang.

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Dan Li, Yi-jun Zhao, Qian Wang and Man-wei Chu share first authorship.

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Li, D., Zhao, Yj., Wang, Q. et al. Fertility preservation in hematological cancer patients. Clin Transl Oncol (2024). https://doi.org/10.1007/s12094-024-03419-2

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