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Synthesis, Characterization of Novel Thiazole Hydrazine Derivatives, and Inhibitory Action Against the VEGFR-2

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Abstract

Objective: Synthesis, characterization of novel thiazole hydrazine derivatives and inhibitory action against the VEGFR-2. Methods: The novel synthesized derivatives were appraised for their ability to inhibit the growth of cancer cells in vitro utilizing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay method. Results and Discussion: The synthesized derivatives divulge moderate to noteworthy in vitro anticancer activity towards the chosen cancer cell lines. Compounds (Va), (Vb), and (Ve) exhibited prominent anticancer activities with IC50 values 10.24–15.44 µM. Conclusions: Amongst these, compound (Va), (Vb), and (Ve) showed the most potent inhibition when compared with other tested compounds. Thus, the reports obtained of the current studies divulge that the thiazole hydrazine derivatives can be developed as auspicious anticancer entities in future.

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DATA AVAILABILITY

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by regular institutional funding, and no additional grants were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Deogiri College, 431005, Aurangabad, India

    V. A. Gore & D. N. Pansare

  2. Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, 431004, Aurangabad, India

    A. P. Sarkate

  3. Department of Pharmaceutical Chemistry, Shri Ramkrishna Paramhas College of Pharmacy, Hasnapur, 431004, Parbhani, India

    S. V. Tiwari

  4. Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, 414001, Ahmednagar, India

    R. N. Shelke

  5. Department of Pharmaceutical Chemistry, A.I.S.S.M.S College of Pharmacy, near RTO, Kennedy Road, Pune, 411001, Maharashtra, India

    S. V. Bhandari

  6. Department of Forensic Chemistry and Toxicology, Government Institute of Forensic Science, 431004, Aurangabad, India

    D. S. Bhagat

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Contributions

The authors VAG and DNP selected the literature data on the review topic. The authors APS, SVT, RNS, SVB, and DSB contributed to manuscript preparation.

All authors participated in the discussions.

Corresponding author

Correspondence to D. N. Pansare.

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This article does not contain any studies involving patients or animals as test objects. Informed consent was not required for this article. No conflict of interest was declared by the authors.

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Abbreviations: MCF-7, Human breast cancer cell line; HepG2, Human liver cancer cell line; TLC, Thin layer chromatography.

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Gore, V.A., Pansare, D.N., Sarkate, A.P. et al. Synthesis, Characterization of Novel Thiazole Hydrazine Derivatives, and Inhibitory Action Against the VEGFR-2. Russ J Bioorg Chem 50, 345–353 (2024). https://doi.org/10.1134/S1068162024020067

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