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Autosis: a new form of cell death in myocardial ischemia–reperfusion injury

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Abstract

Cardiomyocytes undergo a variety of cell death events during myocardial ischemia‒reperfusion injury (MIRI). Understanding the causes of cardiomyocyte mortality is critical for the prevention and treatment of MIRI. Among the various types of cell death, autosis is a recently identified type of autophagic cell death with distinct morphological and chemical characteristics. Autosis can be attenuated by autophagy inhibitors but not reversed by apoptosis or necrosis inhibitors. In recent years, it has been shown that during the late phase of reperfusion, autosis is activated, which exacerbates myocardial injury. This article describes the characteristics of autosis, autophagic cell death, and the relationship between autophagic cell death and autosis; reviews the mechanism of autosis in MIRI; and discusses its clinical significance.

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Acknowledgements

This research was supported by grants from the National Natural Science Foundation of China (Grant Nos.82170260).

Funding

This article was funded by National Natural Science Foundation of China, 82170260, 82170260, 82170260, 82170260, 82170260, 82170260, 82170260.

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Authors and Affiliations

  1. Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, 443003, HuBei Province, China

    Xiaoting Yang, Hui Wu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu & Yi Li

  2. Department of Cardiology, Yichang Central People’s Hospital, Yiling Road 183, Yichang, 443000, HuBei Province, China

    Xiaoting Yang, Hui Wu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu & Yi Li

  3. HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, HuBei Province, China

    Xiaoting Yang, Hui Wu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu & Yi Li

  4. Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People’s Hospital, Yichang, HuBei Province, China

    Xiaoting Yang, Hui Wu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu & Yi Li

  5. Hubei Key Laboratory of Ischemic Cardiovascular Disease, Yichang, HuBei Province, China

    Xiaoting Yang, Hui Wu, Gang Zhou, Dong Zhang, Qingzhuo Yang, Yanfang Liu & Yi Li

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Contributions

Xiaoting Yang contributed toward conceptualization, and writing-original draft preparation. Gang Zhou and Dong Zhang contributed toward data curation. Qingzhuo Yang and Yanfang Liu contributed toward visualization and investigation. Yi Li contributed toward production of matching images. Wu Hui contributed toward supervision. Xiaoting Yang contributed toward writing- reviewing and editing.

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Correspondence to Hui Wu.

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Yang, X., Wu, H., Zhou, G. et al. Autosis: a new form of cell death in myocardial ischemia–reperfusion injury. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-024-04988-0

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