Abstract
A complex interaction among virulence factors, host-genes and host immune system is considered to be responsible for dengue virus (DENV) infection and disease progression. Generation of auto-antibodies during DENV infection is a major phenomenon that plays a role in the pathophysiology of dengue hemorrhagic fever and dengue shock syndrome. Hemostasis, thrombocytopenia, hepatic endothelial dysfunction, and autoimmune blistering skin disease (pemphigus) are different clinical manifestations of dengue pathogenesis; produced due to the molecular mimicry of DENV proteins with self-antigens like coagulation factors, platelets and endothelial cell proteins. This review elaborately describes the current advancements in auto-antibody-mediated immunopathogenesis which inhibits coagulation cascade and promotes hyperfibrinolysis. Auto-antibodies like anti-endothelial cell antibodies-mediated hepatic inflammation during severe DENV infection have also been discussed. Overall, this comprehensive review provides insight to target auto-antibodies that may act as potential biomarkers for disease severity, and a ground for the development of therapeutic strategy against DENV.
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The authors thankfully acknowledge Dr. Arti Soren, Officer-in-charge, Dr. Anjali Chatterjee Regional Research Institute, CCRH, Ministry of AYUSH and Dr. Subhash Kaushik, Director General, CCRH, Ministry of AYUSH, Govt. of India for their support.
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This work was supported by CCRH Research grant, Ministry of AYUSH, Govt. of India (Sanction no. 17–152/2010–11/ CCRH/Tech/Virology Lab/3347).
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Conceptualization: Dr. Satadal Das, Dr.Avipsha Sarkar, Dr. Anirban Roy, Tanusree Ghorai Resources: Dr. Satadal Das Funding acquisition: Dr. Debadatta Nayak Visualization: Dr. Satadal Das, Tanusree Ghorai Writing - original draft: Tanusree Ghorai, Bijita Bhowmick Writing - review & editing: Dr. Satadal Das, Dr. Anirban Roy, Dr.Avipsha Sarkar, Bijita Bhowmick.
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Ghorai, T., Sarkar, A., Roy, A. et al. Role of auto-antibodies in the mechanisms of dengue pathogenesis and its progression: a comprehensive review. Arch Microbiol 206, 214 (2024). https://doi.org/10.1007/s00203-024-03954-0
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DOI: https://doi.org/10.1007/s00203-024-03954-0