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Organization and Role of Bacterial SMC, MukBEF, MksBEF, Wadjet, and RecN Complexes

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Abstract

SMC (Structural maintenance of chromosomes) complexes are key participants in the spatial organization of DNA in all living organisms: in bacteria, archaea and eukaryotes. In bacteria, there are several homologues of SMC complexes that perform seemingly unrelated functions, but function through very similar, highly conserved mechanisms. In recent years, it has been established that SMC complexes are capable of forming loops from DNA (through the so-called loop extrusion), which allows them to be considered as a separate class of DNA translocases. This paper discusses bacterial SMC complexes in comparison with their homologues such as MukBEF, MksBEF, RecN, and Wadjet, as well as with eukaryotic SMC complexes. Their properties, role and functions in the key processes of the bacterial cell are discussed.

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ACKNOWLEDGMENTS

The authors of the work express their gratitude to George Pobegalov for a fruitful discussion of the manuscript of this work.

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The work was supported by the Russian Science Foundation (project no. 22-74-00072).

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  1. Peter the Great St. Petersburg Polytechnic University, Research center of nanobiotechnologies, 195251, St. Petersburg, Russia

    N. E. Morozova, A. S. Potysyeva & A. D. Vedyaykin

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Morozova, N.E., Potysyeva, A.S. & Vedyaykin, A.D. Organization and Role of Bacterial SMC, MukBEF, MksBEF, Wadjet, and RecN Complexes. Cell Tiss. Biol. 18, 115–127 (2024). https://doi.org/10.1134/S1990519X23700074

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