Abstract
Folic acid (FA) is a water-soluble vitamin found in diverse natural sources and is crucial for preserving human health. The risk of health issues due to FA deficiency underscores the need for a straightforward and sensitive FA detection methodology. Carbon dots (CDs) have gained significant attention owing to their exceptional fluorescence performance, biocompatibility, and easy accessibility. Consequently, numerous research studies have concentrated on developing advanced CD fluorescent probes to enable swift and precise FA detection. Despite these efforts, there is still a requirement for a thorough overview of the efficient synthesis of CDs and their practical applications in FA detection to further promote the widespread use of CDs. This review paper focuses on the practical applications of CD sensors for FA detection. It begins with an in-depth introduction to FA and CDs. Following that, based on various synthetic approaches, the prepared CDs are classified into diverse detection methods, such as single sensing, visual detection, and electrochemical methods. Furthermore, persistent challenges and potential avenues are highlighted for future research to provide valuable insights into crafting effective CDs and detecting FA.
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Data Availability
No datasets were generated or analysed during the current study.
Abbreviations
- FA:
-
Folic acid
- CDs:
-
Carbon dots
- HPLC:
-
High-performance liquid chromatography
- MOF:
-
Metal organic framework
- QD:
-
Quantum dot
- CNPs:
-
Carbon nanoparticles
- LOD:
-
Limit of detection
- CQD:
-
Carbon quantum dot
- PL:
-
Photoluminescence
- FRET:
-
Through förster resonance energy transfer
- NCDs:
-
Nitrogen-doped carbon dots
- PL:
-
Photoluminescence
- QY:
-
Quantum yield
- GQDs:
-
Graphene quantum dots
- QCE:
-
Quantum confinement effect
- DFT:
-
Density functional theory
- PET:
-
Photo-induced electron transfer
- UCPL:
-
Up-conversion photoluminescence
- N-CDs:
-
Nitrogen doped carbon dots
- FL:
-
Fluorescence
- OP-CQDs:
-
Orange peel carbon quantum dots
- SERS:
-
Surface-enhanced raman scattering
- AAS:
-
Atomic absorption spectroscopy
- DMF:
-
Dimethyl formamide
- TNT:
-
1,3,6-trinitropyrene
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Acknowledgements
I extend special thanks to the University of Sulaimani and Charmo University for all of their cooperation. K.F.K.
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K.F.K.: Conceptualization, investigation, and writing (original draft). M.K.R.: Investigation and writing (original draft). S.J.M.: Revised the manuscript. H.A.R.: Revised the manuscript. M.S.M.: Revised the manuscript. S.B.A.: Supervision, and revised the manuscript.
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Kayani, K.F., Rahim, M.K., Mohammed, S.J. et al. Recent Progress in Folic Acid Detection Based on Fluorescent Carbon Dots as Sensors: A Review. J Fluoresc (2024). https://doi.org/10.1007/s10895-024-03728-3
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DOI: https://doi.org/10.1007/s10895-024-03728-3