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LMNA p.Arg624His Variant Reduces Lamin Expression at mRNA Level: Elucidating Molecular Pathways toward Cardiac Involvement in Laminopathies

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Fig. 1

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Author notes

  1. Jose Angel Urbano-Moral and Diego Franco contributed equally as senior authors of the manuscript.

Authors and Affiliations

  1. Inherited Cardiac Conditions & Myocardial Diseases Unit; Cardiology Department, University Hospital Jaen, 10 Ejercito Espanol Ave, 23007, Jaen, Spain

    Isabel Jimenez-Alcantara, Jose Maria Segura-Aumente & Jose Angel Urbano-Moral

  2. Department of Experimental Biology, University of Jaen, Jaen, Spain

    Estefania Lozano-Velasco, Sheila Caño-Carrillo, Juan Manuel Castillo-Casas & Diego Franco

  3. Inherited Cardiac Conditions & Myocardial Diseases Unit; Genetics Section, Clinical Analysis Department, University Hospital Jaen, Jaen, Spain

    Ana Belen Garcia-Ruano

Authors
  1. Isabel Jimenez-Alcantara
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  2. Estefania Lozano-Velasco
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  3. Sheila Caño-Carrillo
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  4. Juan Manuel Castillo-Casas
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  5. Ana Belen Garcia-Ruano
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  6. Jose Maria Segura-Aumente
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  7. Jose Angel Urbano-Moral
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  8. Diego Franco
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Corresponding author

Correspondence to Jose Angel Urbano-Moral.

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Ethical Approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. No animal studies were carried out by the authors for this article.

Consent To Publish

The authors affirm that human research participants provided informed consent for publication of the images in Fig. 1b.

Informed Consent

Informed consent was obtained from all patients for being included in the study.

Conflicts Of Interest

The authors declare that they have no conflict of interest.

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Associate Editor Paul J. R. Barton oversaw the review of this article

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Jimenez-Alcantara, I., Lozano-Velasco, E., Caño-Carrillo, S. et al. LMNA p.Arg624His Variant Reduces Lamin Expression at mRNA Level: Elucidating Molecular Pathways toward Cardiac Involvement in Laminopathies. J. of Cardiovasc. Trans. Res. (2024). https://doi.org/10.1007/s12265-024-10512-y

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  • DOI: https://doi.org/10.1007/s12265-024-10512-y

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