N-Butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-3) is an original molecule developed at the Research Zakusov Institute of Pharmacology. GML-3 has both anxiolytic and antidepressant activity, which makes the development of tablets based on it a promising task. Optimization of the pressing process is currently an urgent task of the pharmaceutical industry because this technological stage has a significant impact on the disintegration of tablets and the release of the active pharmaceutical ingredient. The Heckel and Kuenz–Leuenberger models were used to study the pressing process of GML-3 tablets. These models were compared to select the most reliable description of pressing GML-3 tablets from granules. Granules with polyvinylpyrrolidone (PVP) and hydroxypropylmethylcellulose (HPMC) as a binder were used.
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We thank Dr. K. V. Alekseev for advice and valuable comments in preparing the article.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 12, pp. 43 – 48, December, 2023
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Markeev, V.B., Tishkov, S.V., Blynskaya, E.V. et al. Study of the Pressing Process of N-Butyl-N-Methyl-1-Phenylpyrrolo-[1,2-a]Pyrazine-3-Carboxamide (GML-3) Tablets Using Mathematical Modeling Techniques. Pharm Chem J 57, 1998–2003 (2024). https://doi.org/10.1007/s11094-024-03107-z
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DOI: https://doi.org/10.1007/s11094-024-03107-z