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Epidemiology of Parkinson’s Disease: An Update

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Abstract

Purpose of Review

In recent decades, epidemiological understanding of Parkinson disease (PD) has evolved significantly. Major discoveries in genetics and large epidemiological investigations have provided a better understanding of the genetic, behavioral, and environmental factors that play a role in the pathogenesis and progression of PD. In this review, we provide an epidemiological update of PD with a particular focus on advances in the last five years of published literature.

Recent Findings

We include an overview of PD pathophysiology, followed by a detailed discussion of the known distribution of disease and varied determinants of disease. We describe investigations of risk factors for PD, and provide a critical summary of current knowledge, knowledge gaps, and both clinical and research implications. We emphasize the need to characterize the epidemiology of the disease in diverse populations.

Summary

Despite increasing understanding of PD epidemiology, recent paradigm shifts in the conceptualization of PD as a biological entity will also impact epidemiological research moving forward and guide further work in this field.

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Data Availability

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

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  1. Ken and Ruth Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

    Juan R Deliz & Paulina Gonzalez-Latapi

  2. Weill Institute for Neurosciences, Department of Neurology, University of California -San Francisco, San Francisco, CA, USA

    Caroline M. Tanner

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Deliz, J.R., Tanner, C.M. & Gonzalez-Latapi, P. Epidemiology of Parkinson’s Disease: An Update. Curr Neurol Neurosci Rep (2024). https://doi.org/10.1007/s11910-024-01339-w

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