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Short- and long-term post-nephrectomy outcomes for retroperitoneal liposarcoma from a high-volume sarcoma center: a propensity score matching analysis

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Abstract

Background

Multivisceral en bloc resection with the ipsilateral kidney is commonly performed in patients with retroperitoneal liposarcoma (RLPS). We evaluated the effect of nephrectomy on short- and long-term outcomes in patients with RLPS.

Methods

Data from a prospectively maintained database of the Peking University Cancer Hospital Sarcoma Center between April 2011 and August 2022 were analyzed. We classified the RLPS patients who underwent surgery into nephrectomy group (NP) and non-nephrectomy group (non-NP). Patients were matched using a 1:1 propensity score to eliminate baseline differences between groups. Postoperative renal function outcomes, major morbidity, and mortality were analyzed to compare short-term outcomes after nephrectomy. Differences in local recurrence-free survival (LRFS) and overall survival (OS) were compared by Kaplan–Meier analysis with respect to oncological benefits.

Results

In the matched cohort, patients in the NP group had significantly higher postoperative eGFR and CKD stages, but none required dialysis. Patients between NP and non-NP had a comparable major morbidity (p = 0.820) and 60-day mortality (p = 0.475). Patients in the NP group had a higher 5‐year LRFS rates than those in the non-NP group (34.5 vs. 17.8%, p = 0.015), and similar 5‐year OS rates (52.4 vs. 47.1%, p = 0.401). Nephrectomy was an independent risk factor for LRFS, but not for major morbidity or OS.

Conclusions

RLPS resection with nephrectomy is related to a mild progression of renal impairment; however, dialysis is rare. En bloc nephrectomy for complete resection of RLPS is safe and improves local control.

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Data availability

All data obtained from the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

This study was supported by Beijing Municipal Administration of Hospital's Ascent Plan (approval No. DFL20181104), and Science Foundation of Peking University Cancer Hospital (approval No.XKFZ2421 and No.PY202308).

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Authors and Affiliations

  1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepato-Pancreato-Biliary Surgery/Sarcoma Center, Peking University Cancer Hospital & Institute, Beijing, People’s Republic of China

    Guoqiang Xue, Zhen Wang, Bonan Liu, Chengpeng Li, Ang lv, Xiuyun Tian, Jianhui Wu, Hui Qiu & Chunyi Hao

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  1. Guoqiang Xue
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  2. Zhen Wang
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Correspondence to Hui Qiu or Chunyi Hao.

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Xue, G., Wang, Z., Liu, B. et al. Short- and long-term post-nephrectomy outcomes for retroperitoneal liposarcoma from a high-volume sarcoma center: a propensity score matching analysis. Int J Clin Oncol (2024). https://doi.org/10.1007/s10147-024-02530-2

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