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SlicerPIT: software development and implementation for planning and image-guided therapy in photoimmunotherapy

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International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

Photoimmunotherapy is a treatment modality that induces targeted cell death by binding a molecular-targeted drug activated by infrared light to the tumor cells and subsequently illuminating the lesion with infrared light. For deep lesions, a needle catheter is used to puncture the tumor, and an illumination fiber (cylindrical diffuser) is inserted into the catheter lumen for internal illumination. However, it can be challenging to place the cylindrical diffusers in an appropriate position as the deep lesions cannot be often confirmed accurately during surgery.

Materials and methods

We have developed "SlicerPIT", a planning simulation software for photoimmunotherapy. SlicerPIT allows users to place the cylindrical diffuser with its illumination range on preoperative images in 2D and 3D and export the planning data to external image-guided surgical navigation systems. We performed seven cycles of photoimmunotherapy with SlicerPIT in three patients with recurrent head and neck cancer.

Results

Preoperative planning for photoimmunotherapy was conducted using SlicerPIT, which could be imported into the navigation system. During the operation, we punctured the needle catheters along with the treatment plan on the navigation screen. Subsequently, intraoperative CT imaging was performed and overlaid with the preoperative treatment plan to confirm the alignment of the cylindrical diffusers as planned, followed by infrared light illumination. Postoperative imaging showed necrosis and shrinkage of the entire tumor in all cycles.

Conclusion

SlicerPIT allows for detailed preoperative treatment planning and accurate puncture. It may be a valuable tool to improve the accuracy of photoimmunotherapy for deep lesions and improve patient outcomes.

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Acknowledgements

This work was supported by JSPS KAKENHI Grant Numbers JP23K15881, JP21K10037, JP21K07717.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-Ku, Sapporo, 060-8638, Japan

    Takayoshi Suzuki, Satoshi Kano, Masanobu Suzuki, Seijiro Hamada, Hiroshi Idogawa, Nayuta Tsushima & Akihiro Homma

  2. Oral and Maxillofacial Surgery, Department of Oral Patho-Biological Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan

    Yuichi Ashikaga

  3. Department of Dental Medical Laboratory, Hokkaido University Hospital, Sapporo, Japan

    Yuki Wakabayashi

  4. Department of Diagnostic and Interventional Radiology, Kushiro City General Hospital, Kushiro, Japan

    Takeshi Soyama

  5. Department of Advanced and Endoscopic Surgery, School of Medicine, Fujita Health University, Toyoake, Japan

    Yasuhiro Hida

Authors
  1. Takayoshi Suzuki
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  2. Satoshi Kano
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  3. Masanobu Suzuki
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  4. Seijiro Hamada
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  5. Hiroshi Idogawa
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  6. Nayuta Tsushima
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  7. Yuichi Ashikaga
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  8. Yuki Wakabayashi
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  9. Takeshi Soyama
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  10. Yasuhiro Hida
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  11. Akihiro Homma
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Corresponding author

Correspondence to Satoshi Kano.

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Suzuki, T., Kano, S., Suzuki, M. et al. SlicerPIT: software development and implementation for planning and image-guided therapy in photoimmunotherapy. Int J Clin Oncol (2024). https://doi.org/10.1007/s10147-024-02516-0

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  • DOI: https://doi.org/10.1007/s10147-024-02516-0

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