Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(II)/chiral norbornene cooperative catalysis

Bo Ding; Qilin Xue; Han Wei; Jiangwei Chen; Ze-Shui Liu; Hong-Gang Cheng; Hengjiang Cong; Jianting Tang; Qianghui Zhou

doi:10.1039/D4SC01004C

Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(ii)/chiral norbornene cooperative catalysis†

Bo Ding,^a Qilin Xue,^a Han Wei,‡^b Jiangwei Chen,‡^a Ze-Shui Liu,^a Hong-Gang Cheng,

^a Hengjiang Cong,

^a Jianting Tang^c and Qianghui Zhou

*^ab

Author affiliations

* Corresponding authors

^a Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric OptoElectronic Materials, College of Chemistry and Molecular Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China
E-mail: qhzhou@whu.edu.cn

^b The Institute for Advanced Studies, Wuhan University, Wuhan, China

^c Key Laboratory of Water Environment Evolution and Pollution Control in Three Gorges Reservoir, School of Environmental and Chemical Engineering, Chongqing Three Gorges University, Chongqing, China

Abstract

An efficient protocol for the asymmetric synthesis of fluorenols has been developed through an enantioconvergent process enabled by Pd(II)/chiral norbornene cooperative catalysis. This approach allows facile access to diverse functionalized chiral fluorenols with constantly excellent enantioselectivities, applying readily available racemic secondary ortho-bromobenzyl alcohols and aryl iodides as the starting materials.

This article is part of the themed collection: 130th Anniversary of Wuhan University

Supplementary files

Article information

DOI: https://doi.org/10.1039/D4SC01004C
Article type: Edge Article
Submitted: 12 Feb 2024
Accepted: 18 Apr 2024
First published: 25 Apr 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry

Download Citation

Chem. Sci., 2024, Advance Article

Permissions

Request permissions

Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(II)/chiral norbornene cooperative catalysis

B. Ding, Q. Xue, H. Wei, J. Chen, Z. Liu, H. Cheng, H. Cong, J. Tang and Q. Zhou, Chem. Sci., 2024, Advance Article , DOI: 10.1039/D4SC01004C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Science

Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(ii)/chiral norbornene cooperative catalysis†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(II)/chiral norbornene cooperative catalysis

Social activity

Search articles by author

Spotlight

Advertisements