Dehalogenative deuteration of alkyl and aryl bromides by thiyl radical catalysis under visible-light irradiation

Abstract

Herein, we report a mild and practical method for the deuteration of alkyl and aryl bromides by a thiyl radical catalyst and halogen-atom transfer (XAT) using disulfides and silanes under visible-light irradiation. In this study, various organic bromides such as 1°, 2°, and 3°-alkyl bromides and aryl bromides were converted to deuterated products in good to excellent yields and D-incorporation.

Graphical abstract: Dehalogenative deuteration of alkyl and aryl bromides by thiyl radical catalysis under visible-light irradiation

Supplementary files

Article information

Article type
Communication
Submitted
20 Feb 2024
Accepted
23 Apr 2024
First published
26 Apr 2024

Chem. Commun., 2024, Advance Article

Dehalogenative deuteration of alkyl and aryl bromides by thiyl radical catalysis under visible-light irradiation

J. Lee and S. Lee, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC00474D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements