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个人简介

2000年7月博士毕业于华东师范大学后留校任教,2002年任副教授,2007年12月晋升教授,博士生导师。主要从事纳米探针设计与生物成像、生物电分析化学、生物与化学传感等方面的研究工作。在Analytical Chemistry、Advanced Functional Materials、ACS Sensors、Nanoscale、Biosensors & Bioelectronics、ACS Applied Materials & Interfaces等国内外主流学术期刊上发表SCI论文140多篇。入选2009年度教育部新世纪人才、2004年度上海市高校优秀青年教师后备人才及2004年度上海市科委青年科技启明星。获2008年度上海市高校优秀青年教师,2006年度上海市教育发展基金会申银万国奖,2017、2001与2000年上海市科技进步奖获得者。 教育经历 1991年9月—1995年6月:华东师范大学,化学,学士 1995年9月—2000年6月:华东师范大学,分析化学,博士 工作经历 2000年7月—2002年7月:华东师范大学,化学系,讲师 2002年8月—2007年11月:华东师范大学,化学系,副教授 2007年12月—至今:华东师范大学,化学系&化学与分子工程学院,教授 荣誉及奖励 2017年:上海市科技进步奖二等奖 2009年:教育部新世纪人才计划 2008年:上海市优秀青年教师 2006年:申银万国奖 2005年:上海市高校优秀青年教师后备人才 2004年:上海市青年科技启明星 2001年:上海市科技进步奖三等奖 2001年:国家“九五”重点科技攻关优秀成果奖 2000年:上海市科技进步三等奖

研究领域

米探针设计与生物成像 纳米生物分析化学 生物电分析化学

近期论文

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DNA gate-based CRISPR-Cas exponential amplification system for ultrasensitive small extracellular vesicle detection to enhance breast cancer diagnosis Tan, Wenqiao; Zhang, Cuiling*; Cheng, Shasha; Hu, Xinyu; Wang, Man; Xian, Yuezhong* Analytical Chemistry, 2024, 9, 1328-1335. NIR light-controlled DNA nanodevice for amplified mRNA imaging and precise gene therapy Xiang, Miaomiao#; Jiang, Yuelin#; Zhou, Jiajia; Bao, Guochen; Luo, Xianzhu; Zhang, Le; Jin, Dayong; Xian, Yuezhong*; Zhang, Cuiling* Nano Today, 2024, 54, 102110. A near-infrared light-activated nanoprobe for simultaneous detection of hydrogen polysulfide and sulfur dioxide in myocardial ischemia-reperfusion injury Luo, Xianzhu; Zhang, Cuiling*; Yue, Chenyang; Jiang, Yuelin; Yang, Fei; Xian, Yuezhong* Chemical Science, 2023, 14, 14290-14301. Recent advances in responsive lanthanide-doped luminescence nanoprobes in the near-infrared-II window (Invited Review) Luo, Xianzhu; Zhang, Cuiling*; Yu, Zihang; Wen, Shihui; Xian, Yuezhong* TrAC Trends in Analytical Chemistry, 2023, 169, 117368. Dye-sensitized rare-earth-dope d nanoprob e for simultaneously enhanced NIR-II imaging and precise treatment of bacterial infection Zhu, Yingxin#; Luo, Xianzhu#; Yu, Zihang; Wen, Shihui; Bao, Guochen; Zhang, Le; Zhang, Cuiling*; Xian, Yuezhong* Acta Biomaterialia, 2023, 170, 532-542. An erythrocyte membrane-camouflaged fluorescent covalent organic framework for starving/nitric oxide/immunotherapy of triple-negative breast cancer Yuan, Fang; Zhang, Cuiling*; Luo, Xianzhu; Cheng, Shasha; Zhu, Yingxin; Xian, Yuezhong* Chemical Science, 2023, 14, 14182-14192. Polymerase-driven logic signal amplification for the detection of small extracellular vesicle surface proteins and the identification of breast cancer Hu, Xinyu; Cheng, Shasha; Luo, Xianzhu; Xian, Yuezhong*; Zhang, Cuiling* Analytical Chemistry, 2023, 95, 10330-10336. Endogenous stimulus-controlled estradiol@AIEgen-based covalent organic framework for reduction of myocardial ischemia/reperfusion injury Yuan, Fang; Zhang, Cuiling*; Luo, Xianzhu; Shen, Xiaokun; Xian, Yuezhong* Chemical Communications, 2023, 59, 5122-5125. Dual-channel fluorescent probe for the detection of peroxynitrite and glutathione in mitochondria: accurate discrimination of inflammatory and progressing tumor cells Luo, Xianzhu; Zhang, Cuiling*; Yuan, Fang; Cheng, Shasha; Zhu, Yingxin; Xiang, Miaomiao; Hu, Xinyu; Xian, Yuezhong* Analytical Chemistry, 2022, 94, 45, 15790–15800. Cell-Membrane-Anchored Upconversion Nanoprobe for Near-Infrared Light Triggered Cell–Cell Interactions Kong, Yujing; Yuan, Fang; Yang, Fei; Zhang, Cuiling*; Xian, Yuezhong* Analytical Chemistry, 2022, 94, 12024–12032 Ratiometrically pH-Insensitive Upconversion Nanoprobe: Toward Simultaneously Quantifying Organellar Calcium and Chloride and Understanding the Interaction of the Two Ions in Lysosome Function Ding, Caiping; Cheng, Shasha; Yuan, Fang; Zhang, Cuiling*; Xian, Yuezhong* Analytical Chemistry, 2022, 94, 10813-10823 AIEgen-Based sp2 Carbon-Conjugated Covalent Organic Frameworks with High Stability and Emission for Activatable Imaging and Ferroptosis in Target Tumor Cells You, Jia; Yuan, Fang; Cheng, Shasha; Kong, Qianqian; Jiang, Yuelin; Luo, Xianzhu; Xian, Yuezhong*; Zhang Cuiling* Chemistry of Materials, 2022, 34, 7078-7089 An Ultrasensitive Strand Displacement Signal Amplification-Assisted Synchronous Fluorescence Assay for Surface Proteins of Small Extracellular Vesicle Analysis and Cancer Identification Cheng, Shasha; Kong, Qianqian; Hu, Xinyu; Zhang, Cuiling*; Xian, Yuezhong* Analytical Chemistry, 2022, 94, 1085-1091 Rational Synthesis of Imine-Linked Fluorescent Covalent Organic Frameworks with Different pK(a) for pH Sensing In Vitro and In Vivo Yuan, Fang ; Kong, Yujing ; You, Jia; Zhang, Cuiling*; Xian, Yuezhong* ACS Applied Materials & Interfaces, 2021, 13, 51351-5136 Near-Infrared Light Controllable DNA Walker Driven by Endogenous Adenosine Triphosphate for in Situ Spatiotemporal Imaging of Intracellular MicroRNA Ye, Mingqiang; Kong, Yujing; Zhang, Cuiling*; Lv, Yifei; Cheng, Shasha; Hou, Dongyan; Xian, Yuezhong* ACS Nano, 2021, 15, 9, 14253–14262 pH-Sensitive Dye-Based Nanobioplatform for Colorimetric Detection of Heterogeneous Circulating Tumor Cells Wang, Xiuli; Cheng, Shasha; Wang, Xinjun; Wei, Liran; Kong, Qianqian; Ye, Mingqiang; Luo, Xianzhu; Xu, Jiao; Zhang, Cuiling*; Xian, Yuezhong* ACS Sensors, 2021, 6, 5, 1925–1932 Rational Modulation of the Luminescence of Upconversion Nanomaterials with Phycocyanin for the Sensing and Imaging of Myeloperoxidase during an Inflammatory Process You, Yi; Cheng, Shasha; Zhang, Li; Zhu, Yingxin; Zhang, Cuiling;* Xian, Yuezhong* Analytical Chemistry, 2020, 92, 5091-5099 Multivalent Aptamer Functionalized Ag2S Nanodots/Hybrid Cell Membrane-Coated Magnetic Nanobioprobe for the Ultrasensitive Isolation and Detection of Circulating Tumor Cells Ding, Caiping; Zhang, Cuiling;* Cheng, Shasha; Xian, Yuezhong* Advanced Functional Materials, 2020, 30, 1909781 Near-Infrared Light-Switched MoS2 Nanoflakes@Gelatin Bioplatform for Capture, Detection, and Nondestructive Release of Circulating Tumor Cells Wang, Xiuli; Wang, Xinjun; Cheng, Shasha; Ye, Mingqiang; Zhang, Cuiling;* Xian, Yuezhong* Analytical Chemistry, 2020, 92, 3111-3117 A ratiometric fluorescent assay for the detection and bioimaging of alkaline phosphatase based on near infrared Ag2S quantum dots and calcein Cai, Meifang; Ding, Caiping; Wang, Fangfang; Ye, Mingqiang; Zhang, Cuiling;* Xian, Yuezhong* Biosensors & Bioelectronics, 2019, 137, 148-153 Ratiometric Upconversion Luminescence Nanoprobe with Near-Infrared Ag2S Nanodots as the Energy Acceptor for Sensing and Imaging of pH in Vivo Ding, Caiping; Cheng, Shasha; Zhang, Cuiling;* Xiong, Youran; Ye, Mingqiang; Xian, Yuezhong* Analytical Chemistry, 2019, 91, 7181-7188 Nanoscaled luminescent terbium metal-organic frameworks for measuring and scavenging reactive oxygen species in living cells Li, Huaping; Cao, Xuanyu; Fei, Xinyu; Zhang, Shiming; Xian, Yuezhong* Journal of Materials Chemistry B, 2019, 7, 3027-3033 Cationic cyanine chromophore-assembled upconversion nanoparticles for sensing and imaging H2S in living cells and zebrafish Wang, Fangfang; Zhang, Cuiling;* Qu, Xuetong; Cheng, Shasha; Xian, Yuezhong* Biosensors & Bioelectronics, 2019, 126, 96-101 Transition metal dichalcogenide quantum dots: synthesis, photoluminescence and biological applications (Invited Review) Cao, Xuanyu; Ding, Caiping; Zhang, Cuiling*; Gu, Wei; Yan, Yinghan; Shi, Xinhao; Xian, Yuezhong* Journal of Materials Chemistry B, 2018, 6, 8011-8036 Near-Infrared Fluorescent Ag2S Nanodot-Based Signal Amplification for Efficient Detection of Circulating Tumor Cells Ding, Caiping; Zhang, Cuiling;* Yin, Xueyang; Cao, Xuanyu; Cai, Meifang; Xian, Yuezhong* Analytical Chemistry, 2018, 90, 6702-6709 Platinum Nanoparticle Encapsulated Metal-Organic Frameworks for Colorimetric Measurement and Facile Removal of Mercury(II) Li, Huaping; Liu, Huifang; Zhang, Jidong; Cheng, Yuxiao; Zhang, Cuiling;* Fei, Xinyu; Xian, Yuezhong* ACS Applied Materials & Interfaces, 2017, 9, 40716-401725 Rare earth ions enhanced near infrared fluorescence of Ag2S quantum dots for the detection of fluoride ions in living cells Ding, Caiping; Cao, Xuanyu; Zhang, Cuiling;* He, Tangrong; Hua, Nan; Xian, Yuezhong* Nanoscale, 2017, 9, 14031-14038 Black Phosphorus Quantum Dots as the Ratiometric Fluorescence Probe for Trace Mercury Ion Detection Based on Inner Filter Effect Wei Gu, Xueyu Pei, Yuxiao Cheng, Cuiling Zhang,* Jidong Zhang, Yinghan Yan, Caiping Ding, and Yuezhong Xian* ACS Sensors, 2017, 2, 576,582 Label-free upconversion nanoparticles-based fluorescent probes for sequential sensing of Cu2+, pyrophosphate and alkaline phosphatase activity Fangfang Wang, Cuiling Zhang*, Qin Xue, Huaping Li, Yuezhong Xian* Biosensors and Bioelectronics, 2017, 95, 21–26 Highly Fluorescent Polyimide Covalent Organic Nanosheets as Sensing Probes for the Detection of 2,4,6-Trinitrophenol Cuiling Zhang, Shiming Zhang, Yinghan Yan, Fei Xia, Anni Huang, and Yuezhong Xian* ACS Appl. Mater. Interfaces, 2017, 9, 13415,13421 Facile synthesis of water-soluble WS2 quantum dots for turn-on fluorescent measurement of lipoic acid Yinghan Yan, Cuiling Zhang,* Wei Gu, Caiping Ding, Xinchang Li, and Yuezhong Xian* Journal of Physical Chemistry C, 2016, 120, 12170,12177 One-Step synthesis of water-soluble MoS2 quantum dots via a hydrothermal method as a fluorescent probe for hyaluronidase detection Wei Gu, Yinghan Yan, Cuiling Zhang*, Caiping Ding, and Yuezhong Xian* ACS Applied Materials Interfaces, 2016, 8, 11272–11279. Construction of graphene/Au-Nanoparticles/Cucurbit[7]uril-Based Sensor for Pb2+ Sensing Xinhao Shi, Wei Gu, Cuiling Zhang, Longyun Zhao, Li Li,* Weidong Peng, Yuezhong Xian* Chemistry-A European Journal, 2016, 22, 5643-5648. A facile and one-step ethanol-thermal synthesis of MoS2 quantum dots for two-photon fluorescence imaging Wei Gu, Yinghan Yan, Xuni Cao, Cuiling Zhang*, Caiping Ding, Yuezhong Xian* Journal of Materials Chemistry B, 2016, 4(1), 27-31. Controlled growth cerium oxide nanoparticles on reduced graphene oxide for oxygen catalytic reduction Weidong Peng, Longyun Zhao, Cuiling Zhang*, Yinghan Yan, Yuezhong Xian* Electrochimica Acta, 2016, 191, 669–676. MoS2/Nitrogen-doped graphene as efficient electrocatalyst for oxygen reduction reaction Kai Zhao, Wei Gu, Longyun Zhao, Cuiling Zhang*, Weidong Peng, Yuezhong Xian* Electrochimica Acta, 2015, 169, 142-149. A label-free colorimetric sensor for Pb2+ detection based on the acceleration of gold leaching by graphene oxide Xinhao Shi, Wei Gu, Cuiling Zhang*, Longyun Zhao, Weidong Peng and Yuezhong Xian* Dalton Transaction, 2015, 44, 4623-4629 Sensitive Pb2+ probe based on the fluorescence quenching by graphene oxide and enhancement of the leaching of gold nanoparticles Xinhao Shi, Wei Gu, Weidong Peng, Bingyu Li, Ningning Chen, Kai Zhao, Yuezhong Xian* ACS Applied Materials & Interfaces, 2014, 6(4), 2567-2574. Enzymatic biosensors based on the use of metal oxide nanoparticles (Invited Review) Xinhao Shi, Wei Gu, Bingyu Li, Ningning Chen, Kai Zhao, Yuezhong Xian* Microchimica Acta, 2014, 181(1-2), 1-22 Graphene based electrochemical biosensor for label-free measurement of the activity and inhibition of protein tyrosine kinase Bingyu Li, Xinhao Shi, Wei Gu, Kai Zhao, Ningning Chen, Yuezhong Xian* Analyst, 2013, 138 (23), 7212-7217 Synthesis of water-soluble magnetic graphene nanocomposies for recyclable removal of heavy metal ions Wenjing Zhang, Xinhao Shi, Yixuan Zhang, Wei Gu, Bingyu Li, Yuezhong Xian* Journal of Materials Chemistry A, 2013, 1(5), 1745-1753 Bacitracin peptide clicked superparamagnetic iron oxide nanoparticles: synthesis, characterization and antibacterial activity Wenjing Zhang, Xinhao Shi, Jing Huang, Yixuan Zhang, Zirong Wu, Yuezhong Xian* ChemPhysChem, 2012, 13, 3388-3396 A colorimetric sensor based on catechol-terminated mixed self-assembled monolayers modified gold nanoparticles for ultrasensitive detections of copper ions Siqiu Ye, Xinhao Shi, Wei Gu, Yixuan Zhang, Yuezhong Xian* Analyst, 2012, 137 (14), 3365 - 3371 Magnetically controlled bioelectrocatalytic system based on ferrocene-tagged magnetic nanoparticles by thiol-ene reaction Cong Liang, Li Jing, Xinhao Shi, Yixuan Zhang, Yuezhong Xian* Electrochimica Acta, 2012, 69: 167-173 Fluorescent probe for Fe(III) based on pyrene grafted multiwalled carbon nanotubes by click reaction Li Jing, Cong Liang, Xinhao Shi, Siqiu Ye, Yuezhong Xian* Analyst, 2012, 137, 1718-1722 Rhodamine-B decorated superparamagnetic iron oxide nanoparticles: preparation, characterization and their optical/magnetic properties Wenjing Zhang, Yixuan Zhang, Xinhao Shi, Cong Liang, Yuezhong Xian* Journal of Materials Chemistry, 2011, 21,16177 - 16183 An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs Yuan Tian, Siqiu Ye, Xinhao Shi,, Li Jing, Cong Liang, Yuezhong Xian* Analyst, 2011, 136 (23), 5084 - 5090 Direct electrochemistry of horseradish peroxidase immobilized on electrografted 4-ethynylphenyl film via click chemistry Qin Ran, Ru Peng, Cong Liang, Siqiu Ye, Yuezhong Xian,, Wenjing Zhang, Litong Jin Analytica Chimica Acta,2 011, 697: 27–31 Magnetically switchable bioelectrocatalytic system based on ferrocene grafted iron oxide nanoparticles Ru Peng, Wenjing, Zhang, Qin Ran, Cong Liang, Li Jing, Siqiu Ye, Yuezhong Xian* Langmuir, 2011, 27, 2910-2916 Generation of surface-confined catechol terminated sams via electrochemically triggered Michael addition: characterization, electrochemistry and complex with Ni(II) and Cu(II) cations Yuan Tian, Siqiu Ye, Qin Ran, Yuezhong Xian*, Jingjing Xu, Ru Peng, Litong Jin Physical Chemistry Chemical Physics, 2010, 12, 13287-13295. Layer-by-layer assembly of poly(sodium 4-styrenesulfonate) wrapped multiwalled carbon nanotubes with polyaniline nanofibers and its electrochemistry Zhichao Hu, Jingjing Xu, Yuan Tian, Ru Peng, Yuezhong Xian*, Qin Ran, Litong Jin Carbon, 2010, 48, 3729-3736. Ferrocene clicked poly(3,4-ethylenedioxythiophene) conducting polymer: characterization, electrochemical and electrochromic properties Jingjing Xu, Yuan Tian, Ru Peng, Yuezhong Xian*, Qin Ran, Litong Jin Electrochemistry Communications, 2009, 11(10), 1972-1975. High-quality covalently grafting hemoglobin on gold electrode: characterization, redox thermodynamics and bioelectrocatalysis Yuan Tian, Qin Ran, Jingjing Xu, Yuezhong Xian*, Ru Peng, Litong Jin ChemPhysChem, 2009, 10, 3105-3111 Layer-by-layer assembly of polyaniline nanofibers/poly(acrylic acid) multilayer film and electrochemical sensing Zhichao Hu, Jingjing Xu, Yuan Tian, Ru Peng, Yuezhong Xian,, Qin Ran, Litong Jin Electrochimica Acta, 2009, 54, 4056–4061 Covalent grafting nitrophenyl group on Au surface via click reaction: assembling process and electrochemical behaviors Liwei Wang, Yuan Tian, Qin Ran, Zhichao Hu, Jingjing Xu, Yuezhong Xian*, Ru Peng, Litong Jin Electrochemistry Communications, 2009, 11: 339–342 Immobilization of horseradish peroxidase on self-assembled (3-mercaptopropyl)trimethoxysilane film: characterization, direct electrochemistry, redox thermodynamics and biosensing Wu FH, Hu ZC, Xu JJ, Tian Y, Wang LW, Xian YZ*, Jin LT Electrochimica Acta, 2008, 53, 8238-8244 Direct electrochemistry of horseradish peroxidase on TiO2 nanotube arrays via seeded-growth synthesis Wu FH, Xu JJ, Tian Y, Hu ZC, Wang LW, Xian YZ*, Jin LT Biosensors & Bioelectronics, 2008, 24, 198-203 Electric field directed layer-by-layer assembly of horseradish peroxidase nanotubes via anodic aluminum oxide template Wu FH, Hu ZC, Wang LW, Xu JJ, Xian YZ*, Tian Y, Jin LT Electrochemistry Communications, 2008, 10, 630-634 Template synthesis of highly ordered Prussian blue array and its application to the glucose biosensing Xian YZ, Hu Y, Liu F, Xian Y, Feng LJ, Jin LT* Biosensors & Bioelectronics, 2007, 22, 2827-2833 Nanoelectrode ensembles based on conductive polyaniline/poly(acrylic acid) using porous sol-gel films as template Xian YZ, Liu F, Feng LJ, Wu FH, Wang LW, Jin LT* Electrochemistry Communications, 2007, 9, 773-780 Encapsulation hemoglobin in ordered mesoporous silicas: influence factors for immobilization and bioelectrochemistry Xian YZ, Xian Y, Zhou LH, Wu FH, Ling Y, Jin LT* Electrochemistry Communications, 2007, 9, 142-148 Preparation of methylene blue-doped silica nanoparticle and its application to electroanalysis heme proteins Xian YZ, Liu F, Xian Y, Zhou YY, Jin LT* Electrochimica Acta, 2006, 51, 6527-6532 Glucose biosensor based on Au nanoparticles-conductive polyaniline nanocomposite Xian YZ, Hu Y, Liu F, Xian Y, Wang HT, Jin LT* Biosensors & Bioelectronics, 2006, 21, 1996-2000. Preparation of poly(vinylpyrrolidone)-protected Prussian blue nanoparticles-modified electrode and its electrocatalytic reduction for hemoglobin Xian, YZ; Zhou, YY; Xian, Y; Zhou, LH; Wang, HT; Jin, LT* Analytica Chimica Acta, 2005, 546, 139-146 Nanostructured electrode based on multi-wall carbon nanotubes/Pt microparticles nanocomposite for electrochemical determination of thiols in rat striatum by high performance liquid chromatography separation Xian, YZ; Zhou, YY; Wang, HT; Zhou, LH; Liu, F; Jin, LT* Journal of Chromatography B, 2005, 817, 239-246

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