个人简介

王晓云，博士，教授，博士生导师。2002-2003年清华大学访问学者，2008-2010年哈佛大学访问学者，2011年获得高等学校教学名师称号。主持教育部双语建设课程，是国家级教学团队的骨干成员。主持国家自然基金等项目，作为第一作者或通讯作者在“AntioxidantandRedoxsignaling”“ScientificReports”“MolecularGeneticsandGenomics”“InternationalJournalofBiochemistryandCellBiology”“FrontierinPlantScience”“BMCPlantBiol”等学术期刊发表学术论文60多篇。 教学工作 承担本科生《生物化学》、《分子生物学》、《基础生物化学试验》；硕士研究生《生物化学》等课程的教学工作，主持教育部生物化学双语建设课程、山东省首届精品课程和山东省重点建设课程，是国家级教学团队的骨干成员。

研究领域

研究方向 1.生物化学与分子生物学 2.植物抗逆分子生物学

科研项目 1.国家自然科学基金“MdRAf5基因介导的苹果砧木干旱抗性分子调控网络解析” 2.农业部公益性行业科研专项“我国重要野生果树资源的收集、评价与优异种质创新利用技术研究与示范”（主要参加人） 3.国家自然科学基金“利用点突变技术研究二硫键对植酸酶结构、催化活性及热稳定性的作用” 4.国家自然科学基金“通过引物二硫键、增加糖基化位点等方式提高植酸热稳定性的研究” 5.高等学校博士点专项基金：“糖基化及二硫键对植酸酶稳定性的研究” 6.山东省中青年科学家科研奖励基金“叶片衰老关键酶分离纯化及调控衰老物质的研制与开发”

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Xu,J.,Xing,S.,Sun,Q.,Zhan,C.,Liu,X.,Zhang,S.*&Wang,X.Y*.Theexpressionofatubby-likeproteinfromMalusdomestica(MdTLP7)enhancesabioticstresstoleranceinArabidopsis,BMCPlantBiol.2019,19,60. 2.Liu,X.,Li,R.,Dai,Y.,Yuan,L.,Sun,Q.,Zhang,S.*&Wang,X.Y.*AB-boxzincfingerprotein,MdBBX10,enhancedsaltanddroughtstressestoleranceinArabidopsis,PlantMolBiol.2019,doi.org/10.1007/s11103-019-00828-8 3.Li,M.,Wei,G.,Shi,W.,Sun,Z.,Li,H.,Wang,X.Y.*,&Gao,Z.*Distinctdistributionpatternsofammonia-oxidizingarchaeaandbacteriainsedimentandwatercolumnoftheYellowRiverestuary.SciRep,2018,8:1584-1594. 4.Liu,X.,Li,R.,Dai,Y.,Chen,X.,&Wang,X.Y.*Genome-wideidentificationandexpressionanalysisoftheB-boxgenefamilyintheApple(MalusdomesticaBorkh.)genome.MolGenetGenomics.2018,293:303-315 5.Wu,Q.Y.,Zhu,Y.Y.,Wei,F.,Tong,Y.X.,Cao,J.,Zhou,P.,Li,Z.Y.,Zeng,L.Y.,Li,F.,Wang,X.Y.*,&Xu,K.L.MutationoftheconservedG66residueinGSregiondecreasedstructuralstabilityandactivityofargininekinase.IntJBiolMacromol,2018,111:247-254. 6.Zhang,Z.,Liu,X.,Li,R.,Yuan,L.,Dai,Y.,&Wang,X.Y.*Identificationandfunctionalanalysisofaproteindisulfideisomerase(AtPDI1)inArabidopsisthaliana.FrontPlantSci,2018,9:913-923. 7.Zhang,Z.,Yuan,L.,Liu,X.,Chen,X.,&Wang,X.Y*.EvolutionanalysisofDoftranscriptionfactorfamilyandtheirexpressioninresponsetomultipleabioticstressesinMalusdomestica.Gene,2018,639:137-148. 8.Wu,Q.Y.,Wei,F.,Zhu,Y.Y.,Tong,Y.X.,Cao,J.,Zhou,P.,Li,Z.Y.,Zeng,L.Y.,Li,F.,Wang,X.Y.*,&Xu,K.L.RolesofaminoacidresiduesH66andD326inthecreatinekinaseactivityandstructuralstability.IntJBiolMacromol.2017,107:512-520 9.Xu,J.,Xing,S.,Cui,H.,Chen,X.,&Wang,X.Y*.Genome-wideidentificationandcharacterizationoftheapple(Malusdomestica)HECTubiquitin-proteinligasefamilyandexpressionanalysisoftheirresponsivenesstoabioticstresses.MolGenetGenomics,2016,291:635-646. 10.Xu,J.N.,Xing,S.S.,Zhang,Z.R.,Chen,X.S.,&Wang,X.Y*.Genome-Wideidentificationandexpressionanalysisofthetubby-likeproteinfamilyintheMalusdomesticagenome.FrontPlantSci,2016,7:1693. 11.Yu,Z.B.,Yang,X.J.,Du,J.J.,Wan,C.M.,Xu,J.N.,Wang,W.J.,Feng,Y.G.,&Wang,X.Y*.AhomologueofvitaminKepoxidereductaseinSolanumlycopersicumisinvolvedinresistancetoosmoticstress.PhysiolPlant,2016,156(3):311-322. 12.Mao,Y.,Hopkins,D.L.,Zhang,Y.,Li,P.,Zhu,L.,Dong,P.,Liang,R.,Dai,J.,Wang,X.Y.*,&Luo,X.Beefqualitywithdifferentintramuscularfatcontentandproteomicanalysisusingisobarictagforrelativeandabsolutequantitationofdifferentiallyexpressedproteins.MeatSci,2016,118:96-102. 13.YangX.J.,CuiH.R.,YuZ.B.,DuJ.J.,XuJ.N.,andWangX.Y.*,KeyaminoacidsofArabidopsisVKORintheactivityofphylloquinonereductionanddisulfidebondformation.ProteinPeptLett.2015,22:81-86. 14.XuJ.N.,XingS.S.,CuiH.R.,ChenX.S.,andWangX.Y.*,Genome-wideidentificationandcharacterizationoftheapple(Malusdomestica)HECTubiquitin-proteinligasefamilyandexpressionanalysisoftheirresponsivenesstoabioticstresses.MolGenetGenomics.2015.DOI:10.1007/s00438-015-1129-0. 15.LuY.,PengJ.J.,YuZ.B.,DuJ.J.,XuJ.N.,andWangX.Y.*,ThylakoidmembraneoxidoreductaseLTO1/AtVKORisinvolvedinABA-mediatedresponsetoosmoticstressinArabidopsis.PhysiolPlant.2015,154:28-38. 16.LuY.,DuJ.J.,YuZ.B.,PengJ.J.,XuJ.N.,andWangX.Y.*,IdentificationofpotentialtargetsforthylakoidoxidoreductaseAtVKOR/LTO1inchloroplasts.ProteinPeptLett.2015,22:219-225. 17.LiF.,LiW.,LiuY.,TongY.X.,ZhouP.,WangL.,ChenC.,ZengL.Y.,WuQ.Y.,WangX.Y.*,andXuK.L.,EffectsoftheI682FmutationonJAK2'sactivity,structureandstability.IntJBiolMacromol.2015,79:118-125. 18.DuJ.J.,ZhanC.Y.,LuY.,CuiH.R.,andWangX.Y.*,TheconservativecysteinesintransmembranedomainofAtVKOR/LTO1arecriticalforphotosyntheticgrowthandphotosystemIIactivityinArabidopsis.FrontiersinPlantScience.2015,6:238. 19.CuiH.R.,ZhangZ.R.,LvW.,XuJ.N.,andWangX.Y.*,Genome-widecharacterizationandanalysisofF-boxprotein-encodinggenesintheMalusdomesticagenome.MolecularGeneticsandGenomics.2015,290:1-12. 20.JingX.L.,XuJ.,FanM.N.,MaL.,HuangX.,WangX.Y.,SunS.H.,ZhuC.X.,andLiuH.M.,MutationanalysisoftheRNAsilencingsuppressorNS1encodedbyavianinfluenzavirusH9N2.JournalofGeneralVirology.2015,96:1613-1618 21.ZhanC.Y.,XuJ.N.,LiD.,LiuB.B.,FengY.G.,andWangX.Y.*,OverexpressionofAtCBF1inSinningiaspeciosaEnhancesChillingStressTolerance.JournalofBotanicalSciences.2015,S1：26-33. 22.WuQ.Y.,GuoH.Y.,GengH.L.,RuB.M.,CaoJ.,ChenC.,ZengL.Y.,WangX.Y.,LiF.,andXuK.L.,T273playsanimportantroleintheactivityandstructuralstabilityofargininekinase.IntJBiolMacromol.2014,63:21-28. 23.WangP.,LiX.Z.,CuiH.R.,FengY.G.,andWangX.Y*.,Identificationandfunctionalanalysisofanovelparvulin-typepeptidyl-prolylisomerasefromGossypiumhirsutum.PlantPhysiolBiochem.2014,76C:58-66. 24.WanC.M.,YangX.J.,DuJ.J.,LuY.,YuZ.B.,FengY.G.,andWangX.Y*.,IdentificationandcharacterizationofSlVKOR,adisulfidebondformationproteinfromSolanumlycopersicum,andbioinformaticanalysisofplantVKORs.Biochemistry(Mosc).2014,79:440-449. 25.GengH.L.,BianM.R.,LiuY.,CaoJ.,ChenC.,WangZ.Y.,LiZ.Y.,ZengL.Y.,WangX.Y.*,WuQ.Y.,andXuK.L.,TheD14andR138ionpairisinvolvedindimericargininekinaseactivity,structuralstabilityandfolding.IntJBiolMacromol.2014,66:302-310. 26.DuF.,XuJ.N.,ZhanC.Y.,YuZ.B.,andWangX.Y.*,Anobesity-likegeneMdTLP7fromapple(Malusdomestica)enhancesabioticstresstolerance.Biochemicalandbiophysicalresearchcommunications.2014,445:394-397. 27.DuF.,XuJ.N.,LiD.,andWangX.Y.*,Theidentificationofnovelanddifferentiallyexpressedapple-treegenesunderlow-temperaturestressusinghigh-throughputIlluminasequencing.MolBiolRep.2014,42:569-580. 28.YuZ.B.,LuY.,DuJ.J.,PengJ.J.,andWangX.Y.*,ThechloroplastproteinLTO1/AtVKORisinvolvedinthexanthophyllcycleandtheaccelerationofD1proteindegradation.JPhotochemPhotobiolB.2013,130C:68-75. 29.LuY.,WangH.R.,LiH.,CuiH.R.,FengY.G.,andWangX.Y*.,AchloroplastmembraneproteinLTO1/AtVKORinvolvinginredoxregulationandROShomeostasis.PlantCellRep.2013,32:1427-1440. 30.LiF.,WuQ.Y.,andWangX.Y.,TheaminoacidresidueL113isinvolvedinargininekinaseactivityandstructuralstability.IntJBiolMacromol.2013,52:198-205. 31.WuQ.Y.,LiF.,WangX.Y.*,andXuK.L.,EvidencethattheaminoacidresidueIle121isinvolvedinargininekinaseactivityandstructuralstability.IntJBiolMacromol.2012,51:369-377. 32.WuQ.Y.,LiF.,GuoH.Y.,CaoJ.,ChenC.,ChenW.,ZhaoK.,ZengL.Y.,HanZ.X.,LiZ.Y.,WangX.Y.*,andXuK.L.,AminoacidresidueE543inJAK2C618RisapotentialtherapeutictargetformyeloproliferativedisorderscausedbyJAK2C618Rmutation.ArchBiochemBiophys.2012,528:57-66. 33.WuQ.Y.,LiF.,WangX.Y.*,andChenZ.J.,Impactofinter-subunitinteractionsonthedimericargininekinaseactivityandstructuralstability.ArchBiochemBiophys.2011,512:61-68. 34.WuQ.Y.,JinK.Z.,LiF.,HuZ.Q.,andWangX.Y.*,Impactofintra-subunitinteractionsonthedimericargininekinaseactivityandstructuralstability.IntJBiolMacromol.2011,49:822-831. 35.WangX.Y.,DuttonR.J.,BeckwithJ.,andBoydD.,MembranetopologyandmutationalanalysisofMycobacteriumtuberculosisVKOR,aproteininvolvedindisulfidebondformationandahomologueofhumanvitaminKepoxidereductase.AntioxidRedoxSignal.2011,14:1413-1420. 36.WangH.R.,ZhuW.J.,andWangX.Y.*,Mechanismofinhibitionofargininekinasebyflavonoidsconsistentwiththermodynamicsofdockingsimulation.IntJBiolMacromol.2011,49:985-991. 37.JingX.L.,FanM.N.,JiaG.,LiuL.W.,MaL.,ZhengC.C.,ZhuX.P.,LiuH.M.,andWangX.Y.*,AMultifunctionalProteinEncodedbyTurkeyHerpesvirusSuppressesRNASilencinginNicotianabenthamiana.JVirol.2011,85:12792-12803. 38.FengW.K.,WangL.,LuY.,andWangX.Y.*,Aproteinoxidasecatalysingdisulfidebondformationislocalizedtothechloroplastthylakoids.FEBSJ.2011,278:3419-3430. 39.LiF.,WuQ.Y.,SunY.L.,MaN.N.,WangX.Y.,andMengQ.W.,EvidencethattheaminoacidresidueCys117ofchloroplasticmonodehydroascorbatereductaseisinvolvedinitsactivityandstructuralstability.IntJBiolMacromol.2010,46:350-355. 40.WuX.Q.,ZhuW.J.,LuZ.R.,XiaY.,YangJ.M.,ZouF.,andWangX.Y.*,Theeffectofrutinonargininekinase:inhibitionkineticsandthermodynamicsmergingwithdockingsimulation.IntJBiolMacromol.2009,44:149-155. 41.WuX.Q.,XuH.,YueH.,LiuK.Q.,andWangX.Y.*,Inhibitionkineticsandtheaggregationofalpha-glucosidasebydifferentdenaturants.ProteinJ.2009,28:448-456. 42.WuQ.Y.,LiF.,andWangX.Y.*,Val65playsanimportantroleinthesubstratesynergism,structuralstabilityandactivityofargininekinase.IntJBiolMacromol.2009,45:393-398. 43.ShiX.W.,SunM.L.,ZhouB.,andWangX.Y.*,Identification,characterization,andoverexpressionofaphytasewithpotentialindustrialinterest.CanJMicrobiol.2009,55:599-604. 44.ZhouJ.P.,YangZ.B.,YangW.R.,WangX.Y.,JiangS.Z.,andZhangG.G.,EffectsofaNewRecombinantPhytaseonthePerformanceandMineralUtilizationofBroilersFedPhosphorus-DeficientDiets.TheJournalofAppliedPoultryResearch.2008,17:331. 45.WuQ.Y.,LiF.,andWangX.Y.*,Evidencethatamino-acidresiduesareresponsibleforsubstratesynergismoflocustargininekinase.InsectBiochemMolBiol.2008,38:59-65. 46.WuQ.Y.,LiF.,andWangX.Y.*,EvidencethattheaminoacidresidueP272ofargininekinaseisinvolvedinitsactivity,structureandstability.IntJBiolMacromol.2008,43:367-372. 47.ZhuW.J.,LiM.,andWangX.Y.*,Chemicalmodificationstudiesonargininekinase:essentialcysteineandarginineresiduesattheactivesite.IntJBiolMacromol.2007,41:564-571. 48.ZhaoD.M.,WangM.,MuX.J.,SunM.L.,andWangX.Y.*,Screening,cloningandoverexpressionofAspergillusnigerphytase(phyA)inPichiapastoriswithfavourablecharacteristics.LettApplMicrobiol.2007,45:522-528. 49.XiaY.,ParkY.D.,MuH.,ZhouH.M.,WangX.Y.*,andMengF.G.,Theprotectiveeffectsofosmolytesonargininekinaseunfoldingandaggregation.IntJBiolMacromol.2007,40:437-443. 50.WuQ.Y.,LiF.,ZhuW.J.,andWangX.Y.*,Cloning,expression,purification,andcharacterizationofargininekinasefromLocustamigratoriamanilensis.CompBiochemPhysiolBBiochemMolBiol.2007,148:355-362.