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研究领域

蛋白质结构与功能;蛋白质与药物分子相互作用;蛋白组学 主要研究领域包括开发核磁共振等仪器分析方法研究人体内重要蛋白质的结构和功能,蛋白质与药物分子的相互作用机制,胶原蛋白多肽自组装的分子机制及在生物材料中的应用,以及胶原蛋白相关疾病的蛋白组学研究。

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Osteogenesis imperfecta missense mutations in collagen: structural consequences of a glycine to alanine replacement at a highly charged site. Biochemistry 2011, 50, 10771-80. Osteogenesis imperfecta model peptides: incorporation of residues replacing Gly within a triple helix achieved by renucleation and local flexibility. Biophysical Journal 2011,101, 449-458. Local conformation and dynamics of isoleucine in the collagenase cleavage site provides recognition signal for matrix metalloproteinases. Journal of Biological Chemistry 2010, 285, 34181-34190. Structural insights from 15N relaxation data for an anisotropic collagen peptide. Journal of the American Chemical Society 2009, 131, 18194. NMR monitoring of chain-specific stability in heterotrimeric collagen peptides. Journal of the American Chemical Society 2008, 130, 13520.

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