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复杂体系中的多组分同时定性与定量分析、药物与蛋白质相互作用研究、药物分子设计 目前主要从事复杂体系中的多组分同时定性与定量分析、实验条件优化、药物分子与蛋白质相互作用模拟、药物分子设计及计算机技术应用等相关的教学与科研工作。

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B. Q. Li, J. Chen, J. J. Li, X. Wang, H. L. Zhai*. The application of Tchebichef moment method on the quantitative analysis of multiple compounds based on three-dimensional HPLC fingerprint spectra. Analyst, 2015, 140(2): 630-636. J. Chen, B. Q. Li, H. L. Zhai*, W. J. Lü, X. Y. Zhang. A practical application of wavelet moment method on the quantitative analysis of Shuanghuanglian oral liquid based on three-dimensional fingerprint spectra. Journal of Chromatography A, 2014, 1352: 55-61. H. L. Zhai*, B. Q. Li, Y. L. Tian, P. Z. Li, X. Y. Zhang. An application of wavelet moments to the similarity analysis of three-dimensional fingerprint spectra obtained by high-performance liquid chromatography coupled with diode array detector. Food Chemistry, 2014, 145: 625-631. H. L. Zhai*, Y. Y. Zhai, P. Z. Li, Y. L. Tian. A simple approach to the quantitative analysis using three-dimensional spectra based on the selected Zernike moments. Analyst, 2013, 138(2): 683-687. H. L. Zhai*, Z. J. Shan, R. N. Li, E Yu. Simultaneous quantitative analysis of three compounds using three-dimensional fluorescence spectra based on digital image techniques. Journal of Fluorescence, 2012, 22(4): 1013-1019. X. Y. Huang, Z. J. Shan, H. L. Zhai*, L. N. Li, X. Y. Zhang. Molecular design of anticancer drug leads based on three-dimensional quantitative structure-activity relationship. Journal of Chemical Information and Modeling, 2011, 51(8): 1999-2006. X. Y. Huang, Z. J. Shan, H. L. Zhai*, L. Shu, X. Y. Zhang. Study on the anticancer activity of coumarin derivatives by molecular modeling. Chemical Biology & Drug Design, 2011, 78(4): 651-658. H. L. Zhai*, X. H. Wang, X. Y. Huang, Z. J. Shan. The analysis of core promoter sequences based on their chemical features. Chemometrics and Intelligent Laboratory Systems, 2011, 107(2): 245-250. H. L. Zhai*, F. D. Hu, X. Y. Huang, J. H. Chen. The application of digital image recognition to the analysis of two-dimensional fingerprints. Analytica Chimica Acta, 2010, 657: 131-135. H. L. Zhai*, Y. T. Chang, C. C. Wu, J. S. Yu*. An approach to the elimination of inter-individual variability in tumor detection. Analyst, 2010, 135: 875-879.

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