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个人简介

学习经历 2008.09-2012.07 国家纳米科学中心,物理化学,理学博士 2005.09-2008.07 西北农林科技大学,细胞生物学,理学硕士 2001.09-2005.07 西北农林科技大学,动物医学,农学学士 工作经历 2019.5-至今 暨南大学,化学与材料学院,教授 2017.07-2019.04 苏州大学,功能纳米与软物质研究院,副教授 2017.07-2018.07 UNC Chapel Hill(美国),药学院,访问学者 2012.08-2017.06 苏州大学,功能纳米与软物质研究院,讲师

研究领域

1. 纳米材料生物学效应 2. 纳米佐剂材料的精确设计与调控 3. 基于纳米材料的肿瘤免疫治疗新策略

近期论文

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Haoqiang Lai, Ligeng Xu*, Chang Liu, Sujiang Shi, Yalin Jiang, Yangyang Yu, Bo Deng, Tianfeng Chen*. Universal selenium nanoadjuvant with immunopotentiating and redox-shaping activities inducing high-quality immunity for SARS-CoV-2 vaccine. Signal Transduction and Targeted Therapy, 2023, 8, 88 (IF 38.104). Yahui Yang, Yalin Jiang, Bin Xie, Sujiang Shi, Fen Pi, Mingkai Chen, Chengcheng Sang, Ligeng Xu*, Tianfeng Chen*. Selenadiazole derivative-loaded metal azolate frameworks facilitate NK cell immunotherapy by sensitizing tumor cells and shaping immuno[1]suppressive microenvironments. Biomaterials Science, 2023, 11, 1517-1529 (IF 7.59). Qi Chen#, Lizhen He#, Xiaoying Li, Ligeng Xu*, Tianfeng Chen*. Ruthenium complexes boost NK cell immunotherapy via sensitizing triple-negative breast cancer and shaping immuno-microenvironment. Biomaterials, 2022, 281, 121371 (IF 15.304). Ting Liu#, Ligeng Xu#, Lizhen He, Jianfu Zhao, Zehang Zhang, Qi Chen, Tianfeng Chen*. Selenium nanoparticles regulates selenoprotein to boost cytokine-induced killer cells-based cancer immunotherapy. Nano Today, 2020, 35, 100975 (IF 18.962). Yahui Yang, Yifan Wang, Ligeng Xu*, Tianfeng Chen*. Dual-functional Se/Fe complex facilitates TRAIL treatment against resistant tumor cells via modulating cellular endoplasmic reticulum stress. Chinese Chemical Letters, 2020, 31, 1801-1806 (IF 8.455). Rong Yang, Jun Xu, Ligeng Xu*, Xiaoqi Sun, Qian Chen, Yuhuan Zhao, Rui Peng*, Zhuang Liu*. Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination. ACS Nano, 2018, 12, 5121-5129 (IF 18.027, ESI高被引论文,他引374次). Guangbao Yang#, Ligeng Xu#, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu*. Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nature Communications, 2017, 8, 902. (IF 17.694, ESI高被引论文, 他引886次) Jun Xu, Ligeng Xu*, Chenya Wang, Rong Yang, Qi Zhuang, Xiao Han, Ziliang Dong, Wenwen Zhu, Rui Peng*, Zhuang Liu*. Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer. ACS Nano, 2017, 11, 4463-4474 (IF 18.027, ESI高被引论文, 他引497次). Jingjing Liu, Kai Liu, Liangzhu Feng, Zhuang Liu, Ligeng Xu*. Comparison of nanomedicine-based chemotherapy, photodynamic therapy and photothermal therapy using reduced graphene oxide for the model system. Biomaterials Science, 2017, 5, 331-340. (IF 7.59) Qian Chen#, Ligeng Xu#, Chao Liang, Chao Wang, Rui Peng, Zhuang Liu*. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nature Communications, 2016, 7, 13193. (IF 17.694, ESI高被引论文, 他引1035次) Wenwen Zhu, Ziliang Dong, Tingting Fu, Jingjing Liu, Qian Chen, Yonggang Li, Ran Zhu*, Ligeng Xu*, Zhuang Liu*. Modulation of hypoxia in solid tumor microenvironment with MnO2 nanoparticles to enhance photodynamic therapy. Advanced Functional Materials, 2016, 26, 5490-5498 (IF 19.924, ESI高被引论文, 他引456次) Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu*, Rui Peng*. Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity. Nanoscale, 2016, 8, 3785-3795. (IF 8.307, 2016 Hot Articles in Nanoscale) Yinchan Luo, Xinxing Yang, Xiaofang Tan, Ligeng Xu*, Zhuang Liu, Jie Xiao, Rui Peng*. Functionalized graphene oxide in microbial engineering: an effective stimulator for bacterial growth. Carbon, 2016, 103, 172-180. (IF 11.307) Ligeng Xu, Jian Xiang, Rui Peng*, Zhuang Liu*. Recent advances in the development of nanomaterials for DC-based immunotherapy. Science Bulletin, 2016, 61, 514-523. (Invited review, IF 20.577) Jian Xiang, Ligeng Xu*, Hua Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng, Rui Peng*, Zhuang Liu*. Antigen-loaded upconversion nanoparticles for dendritic cell stimulation, tracking, and vaccination in dendritic cell-based immunotherapy. ACS Nano, 2015, 9, 6401-6411. (IF 18.027, 他引147次) Hua Gong, Jian Xiang, Ligeng Xu*, Xuejiao Song, Ziliang Dong, Rui Peng*, Zhuang Liu*. Stimulation of immune systems by conjugated polymers and their potential as an alternative vaccine adjuvant. Nanoscale, 2015, 7, 19282-19292. (IF 8.307) Liming Qu, Jinhai Xu, Xiaofang Tan, Zhuang Liu, Ligeng Xu*, Rui Peng*. Dual-aptamer modification generates a unique interface for highly sensitive and specific electrochemical detection of tumor cells. ACS Applied Materials & Interfaces, 2014, 6, 7309-7315. (IF 10.383) Ligeng Xu, Liang Cheng, Chao Wang, Rui Peng*, Zhuang Liu*. Conjugated polymers for photothermal therapy of cancer. Polymer Chemistry, 2014, 5, 1573-1580. (Invited review, IF 5.364, 2014’s most accessed Polymer Chemistry Top10 articles,他引197次) Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Liying Ma, Yiming Shao*, Yuliang Zhao*, Chunying Chen*. Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine. Advanced Materials, 2013, 25, 5928-5936. (IF 32.086, Highlighted by MaterialsViews China, 他引98次) igeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Yong Liu, Xiaochun Wu*, Yinglu Ji, Yuliang Zhao, Liying Ma, Yiming Shao, Chunying Chen*. Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment. Nano Letters, 2012, 12, 2003-2012. (IF 12.262, 他引234次) Ligeng Xu, Chunying Chen*. Physiological behavior of quantum dots. WIRES Nanomedicine Nanobiotechnology, 2012, 4, 620-637. (Invited review, IF 9.423) Ligeng Xu, Ying Liu, Ru Bai, Chunying Chen*. Applications and toxicological issues surrounding nanotechnology in the food industry. Pure and Applied Chemistry, 2010, 82, 349-372 (IF 2.32). 许利耕, 陈春英*. 纳米材料作为重大疾病疫苗载体或佐剂的研究进展. 科学通报, 2012, 57, 2341-2353 (封面文章).

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