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个人简介

获奖 1.2003年广东省科技进步二等奖,参与者,Duchenne肌营养不良症的机制和实验治疗。 2.1996年国家科技进步三等奖,参与者,抗癫痫药的基础和临床研究。 3.1994年四川省科技进步一等奖,参与者,抗癫痫药的基础和临床研究。

研究领域

(1)Alzheimer's病的细胞和突触机制;(2)Alzheimer's病的新药分子筛选和探索;(3)穴位和经络的物质基础探索

基金(主持) 1.国家自然科学基金项目:Furin通过内体转运途径调节APP降解并参与阿尔茨海默病(81971030),55万,2020-2023 2.科技部重点研发计划项目,基于医体结合的记忆和运动障碍三级全程化诊疗模式研究(2018YFC1314700)。子课题负责,230万(共880万),2019-2020 3.重庆市科委面上项目:MMP13对BACE1的调控机制及其对阿尔茨海默病治疗价值的实验研究(Cstc2018jcyjAX0067),10万,2019-2020 4.国家自然科学基金国际合作重大项目,钙通道调节异常的分子机制与阿尔茨海默病,(81220108010),290万,2013-2017. 5.国家自然科学基金,A-beta在中间神经元损害nAChR介导兴奋性机制研究(81171197)。55万,2012-2015.

近期论文

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近期英文文章(第一/通讯) [1]X.J.Xiang,L.Song,X.J.Deng,Y.Tang,Z.Min,B.Luo,Q.X.Wen,K.Y.Li,J.Chen,Y.L.Ma,B.L.Zhu,Z.Yan,G.J.Chen,MitochondrialmethioninesulfoxidereductaseB2linksoxidativestresstoAlzheimer'sdisease-likepathology,ExpNeurol,318(2019)145-156.IF4.48 [2]Y.J.Lai,B.L.Zhu,F.Sun,D.Luo,Y.L.Ma,B.Luo,J.Tang,M.J.Xiong,L.Liu,Y.Long.,L.He,X.J.Deng,J.H.Zhang,J.Yang,Z.Yan6,G.J.Chen,EstrogenreceptorapromotesCav1.2ubiquitinationanddegradationinneuronalcellsandinAPP/PS1mice,AgingCell,2019,InPress(DOI10.1111/acel.12961).IF7.63. [3]B.L.Zhu,Y.Long,W.Luo,Z.Yan,Y.J.Lai,L.G.Zhao,W.H.Zhou,Y.J.Wang,L.L.Shen,L.Liu,X.J.Deng,X.F.Wang,F.Sun,G.J.Chen,MMP13inhibitionrescuescognitivedeclineinAlzheimertransgenicmiceviaBACE1regulation,Brain:ajournalofneurology,142(2019)176-192.IF11.81. [4]Z.Min,Y.Tang,X.T.Hu,B.L.Zhu,Y.L.Ma,J.S.Zha,X.J.Deng,Z.Yan,G.J.Chen,CosmosiinIncreasesADAM10ExpressionviaMechanismsInvolving5'UTRandPI3KSignaling,Frontiersinmolecularneuroscience,11(2018)198.IF3.90 [5]B.Zhu,L.Zhao,D.Luo,D.Xu,T.Tan,Z.Dong,Y.Tang,Z.Min,X.Deng,F.Sun,Z.Yan,G.Chen,Furinpromotesdendriticmorphogenesisandlearningandmemoryintransgenicmice.Cell.Mol.LifeSci.2018;75(13):2473-88.IF7.01. [6]Y.Tang,Z.Min,X.J.Xiang,L.Liu,Y.L.Ma,B.L.Zhu,L.Song,J.Tang,X.J.Deng,Z.Yan,G.J.Chen,Estrogen-relatedreceptoralphaisinvolvedinAlzheimer'sdisease-likepathology,ExpNeurol,305(2018)89-96.IF4.70 [7]X.T.Hu,B.L.Zhu,L.G.Zhao,J.W.Wang,L.Liu,Y.J.Lai,L.He,X.J.Deng,G.J.Chen,Histonedeacetylaseinhibitorapicidinincreasesexpressionofthealpha-secretaseADAM10throughtranscriptionfactorUSF1-mediatedmechanisms,FASEBJ,31(2017)1482-1493.IF5.50 [8]J.S.Zha,B.L.Zhu,L.Liu,Y.J.Lai,Y.Long,X.T.Hu,X.J.Deng,X.F.Wang,Z.Yan,G.J.Chen,PhorbolestersdPPA/dPApromotefurinexpressioninvolvingtranscriptionfactorCEBPbetainneuronalcells,Oncotarget,8(2017)60159-60172.IF5.17 [9]J.Yang,A.Y.Liu,B.Tang,D.Luo,Y.J.Lai,B.L.Zhu,X.F.Wang,Z.Yan,G.J.Chen,Chronicnicotinedifferentiallyaffectsmurinetranscriptomeprofilinginisolatedcorticalinterneuronsandpyramidalneurons,BMCGenomics,18(2017)194.IF3.73 [10]Y.J.Lai,D.Yu,J.H.Zhang,G.J.Chen,CooperationofGenomicandRapidNongenomicActionsofEstrogensinSynapticPlasticity,MolNeurobiol,54(2017)4113-4126.IF6.19 [11]Y.J.Lai,L.Liu,X.T.Hu,L.He,G.J.Chen,EstrogenModulatesubc9ExpressionandSynapticRedistributionintheBrainofAPP/PS1MiceandCorticalNeurons,JMolNeurosci,61(2017)436-448.IF2.23 [12]L.T.Hu,B.L.Zhu,Y.J.Lai,Y.Long,J.S.Zha,X.T.Hu,J.H.Zhang,G.J.Chen,HMGCS2promotesautophagicdegradationoftheamyloid-betaprecursorproteinthroughketonebody-mediatedmechanisms,BiochemBiophysResCommun,486(2017)492-498.IF2.47 [13]X.Y.Xu,C.Q.Deng,J.Wang,X.J.Deng,Q.Xiao,Y.Li,Q.He,W.H.Fan,F.Y.Quan,Y.P.Zhu,P.Cheng,G.J.Chen,PlasmaLevelsofSolubleReceptorforAdvancedGlycationEndProductsinAlzheimerDisease,IntJNeurosci,(2016)1-18.IF2.05 [14]L.He,X.T.Hu,Y.J.Lai,Y.Long,L.Liu,B.L.Zhu,G.J.Chen,RegulationandtheMechanismofEstrogenonCav1.2GeneinRat-CulturedCorticalAstrocytes,JMolNeurosci,60(2016)205-213.IF2.23 [15]W.Fan,Y.Long,Y.Lai,X.Wang,G.Chen,B.Zhu,NPAS4FacilitatestheAutophagicClearanceofEndogenousTauinRatCorticalNeurons,JMolNeurosci,58(2016)401-410.IF2.23 [16]Q.Cao,W.Wang,J.Gu,G.Jiang,X.Bian,K.Wang,Z.Xu,J.Li,G.Chen,X.Wang,ElevatedExpressionofAcid-SensingIonChannel3InhibitsEpilepsyviaActivationofInterneurons,MolNeurobiol,53(2016)485-498.IF5.29 [17]Z.Xu,P.Xu,Y.Chen,J.Liu,Y.Zhang,Y.Lv,J.Luo,M.Fang,J.Zhang,J.Wang,K.Wang,X.Wang,G.Chen,ENT1inhibitionattenuatesepilepticseizureseverityviaregulationofglutamatergicneurotransmission,NeuromolecularMed,17(2015)1-11.IF3.29 [18]B.Tang,D.Luo,J.Yang,X.Y.Xu,B.L.Zhu,X.F.Wang,Z.Yan,G.J.Chen,ModulationofAMPAreceptormediatedcurrentbynicotinicacetylcholinereceptorinlayerIneuronsofratprefrontalcortex,SciRep,5(2015)14099.IF5.23 [19]H.B.Shi,B.Tang,Y.W.Liu,X.F.Wang,G.J.Chen,Alzheimerdiseaseandcancerrisk:ameta-analysis,JCancerResClinOncol,141(2015)485-494.IF3.14 [20]D.Luo,Y.Long,G.J.Chen,Cyclooxygenase-2genepolymorphismsandriskofAlzheimer'sdisease:Ameta-analysis,JNeurolSci,359(2015)100-105.IF2.47 [21]G.Jiang,W.Wang,Q.Cao,J.Gu,X.Mi,K.Wang,G.Chen,X.Wang,Insulingrowthfactor-1(IGF-1)enhanceshippocampalexcitatoryandseizureactivitythroughIGF-1receptor-mediatedmechanismsintheepilepticbrain,ClinSci(Lond),129(2015)1047-1060.IF5.6 [22]X.Zhang,G.Chen,Y.Lu,J.Liu,M.Fang,J.Luo,Q.Cao,X.Wang,Associationofmitochondrialletm1withepilepticseizures,CerebCortex,24(2014)2533-2540.IF8.31 [23]G.J.Chen,Z.Xiong,Z.Yan,Abetaimpairsnicotinicregulationofinhibitorysynaptictransmissionandinterneuronexcitabilityinprefrontalcortex,MolNeurodegener,8(2013)3.IF5.29 [24]Y.Xu,K.Zeng,Y.Han,L.Wang,D.Chen,Z.Xi,H.Wang,X.Wang,G.Chen,AlteredexpressionofCX3CL1inpatientswithepilepsyandinaratmodel,AmJPathol,180(2012)1950-1962.IF4.52 [25]Y.Xu,J.Luo,Z.Yue,L.Wu,X.Zhang,C.Zhou,F.Zhao,X.Wang,G.Chen,Increasedexpressionofplacentalgrowthfactorinpatientswithtemporallobeepilepsyandaratmodel,BrainRes,1429(2012)124-133.IF2.88 [26]J.Luo,K.Zeng,C.Zhang,M.Fang,X.Zhang,Q.Zhu,L.Wang,W.Wang,X.Wang,G.Chen,Down-regulationofCRMP-1inpatientswithepilepsyandaratmodel,NeurochemRes,37(2012)1381-1391.IF2.12 [27]Y.Hu,X.Huang,D.Shen,M.Ding,H.Sun,B.Peng,X.Hu,H.Li,K.Zeng,Z.Xi,Y.Zhang,Q.Cao,J.Liu,Y.Zhou,M.Wu,Y.Lu,G.Chen,X.Wang,Outcomesofsustained-releaseformulationofvalproateandtopiramatemonotherapyinpatientswithepilepsy:amulti-centre,cohortstudy,PLoSOne,7(2012)e47982.IF3.73 [28]Y.Han,H.Yin,Y.Xu,Q.Zhu,J.Luo,X.Wang,G.Chen,Increasedexpressionofcalponin-3inepilepticpatientsandexperimentalrats,ExpNeurol,233(2012)430-437.IF4.65

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