张子张 - 浙江大学

研究领域

张子张博士的主要研究兴趣在于生物大分子与化学小分子之间相互作用的机制, 研究分以下三个方面: 基因组化学，生物转化与催化，不对称合成基因组化学(genochemistry）针对基因组时代生命科学与化学科学研究信息与数据的海量涌现以及由此产生的新的挑战，张子张博士提出了“基因组化学”的概念并致力于该领域理论体系与方法学的探讨和研究，试图在更加基础的基因组水平研究物种的基因型及化学表现型之间的关系，期望这种研究能对未来生命科学研究，医药研究，疾病诊断及治疗等提供更多的科学依据，方法与手段。

近期论文

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Towards Genochemistry: Harnessing the Power of Biocatalysis for Research in Life Sciences, Zizhang Zhang and Att-ur-Rahman Current Organic Chemistry, 2010, 14, 1902-1913 社论: Meeting grand goals Zizhang Zhang，Current Organic Chemistry, 2010, 14, 1869 Use of whole cell culture of Aeromonas sp. as enantioselective scavenger: A facile preparation of l-amino acid derivatives in high enantiomeric excess Zizhang Zhang, Bioorganic & Medicinal Chemistry Letters, 2009, 19，1129-1131 Enantioselective Scavenging Using Homogenate of Rhodotorula graminis: A Facile Preparation of D-Amino Acid Derivatives in Enantiopure Form Zizhang Zhang, Tetrahedron Letters, 2008, 49, 6468-6470 Mechanism and Application of Asymmetric Dihydroxylation of Olefins Catalyzed by Aspergillus niger 黑曲霉催化烯烃的不对称双羟基化反应的机理和应用 Zizhang Zhang（张子张）, J. Mol. Cata.（分子催化），2008，1，80 EHPred: an SVM-based method for classification of epoxide hydrolases Jia Jia, Liang Yang and Zizhang Zhang,* J.Zhejiang Univ SCIENCE B 2006 7（1）：1-6 Complete Genome Sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04) Shengli Bi, Ede Qin, Zuyuan Xu, Wei Li, Jing Wang, Yongwu Hu, Yong Liu, Shumin Duan, Jianfei Hu, Yujun Han, Jing Xu, Yan Li, Yao Yi, Yongdong Zhou, Wei Lin, Jie Wen, Hong Xu, Ruan Li, Zizhang Zhang, Haiyan Sun, Jingui Zhu, Man Yu, Baochang Fan, Qingfa Wu, Wei Lin, Lin Tang, Bao'an Yang, Guoqing Li, Wenming Peng, Wenjie Li, Tao Jiang, Yajun Deng, Bohua Liu, Jianping Shi, Yongqiang Deng, Wei Wei, Hong Liu, Zongzhong Tong , Feng Zhang , Yu Zhang , Cui'e Wang , Yuquan Li, Jia Ye, Yonghua Gan, Jia Ji, Xiaoyu Li, Xiangjun Tian, Fushuang Lu, Gang Tan, Ruifu Yang, Bin Liu, Siqi Liu, Songgang Li, Jun Wang, Jian Wang, Wuchun Cao, Jun Yu, Xiaoping Dong, Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 3 Evolution and Variation of the SARS-CoV Genome Jianfei Hu , Jing Wang , Jing Xu , Wei Li , Yujun Han , Yan Li , Jia Ji , Jia Ye , Zhao Xu , Zizhang Zhang , Wei Wei , Songgang Li , Jun Wang , Jian Wang , Jun Yu , Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 3 Genome Organization of the SARS-CoV Jing Xu, Jianfei Hu, Jing Wang, Yujun Han, Yongwu Hu, Jie Wen, Yan Li, Jia Ji, Jia Ye, Zizhang Zhang, Wei Wei, Songgang Li, Jun Wang, Jian Wang, Jun Yu, Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 3 The R Protein of SARS-CoV: Analyses of Structure and Function Based on Four Complete Genome Sequences of Isolates BJ01-BJ04 Zuyuan Xu, Haiqing Zhang, Xiangjun Tian, JIA Ji, Wei Li, Yan Li, Wei Tian, Yujun Han, Lili Wang, Zizhang Zhang, Jing Xu, Wei Wei, Jingui Zhu, Haiyan Sun, Xiaowei Zhang, Jun Zhou, Songgang Li, Jun Wang, Jian Wang, Shengli Bi, Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 2 First preparation of enantiopure indane monomer, (S)-(-)–and (R)-(+)-2,3-dihydro-3- (4’-hydroxyphenol)-1,1,3-trimethyl-1H-inden-5-ol, via a unique enantio- and regioselective enzymatic kinetic resolution M.Zhang*, R. Kazlauskas, J. Org. Chem. 1999, 64, 7498-7503