段文虎 - 华东理工大学

研究领域

1. 具有重要生理活性的天然产物合成和构效关系研究。我们课题组已完成了红根草邻醌、紫丹参甲素、3, 17－二羟基丹参酮、紫草素、曲古抑菌素和霉酚酸等天然产物的全合成。 2. 针对抗肿瘤药物的新靶点如端粒酶（telomerase）、组蛋白脱乙酰酶（HDAC）和表皮生长因子受体（ EGFR）等，设计和合成具有新型作用机制的抗肿瘤药物。 3. 针对N-甲基-D-天冬氨酸（NMDA）受体，设计和合成新型作用机制的神经系统疾病治疗药物。

近期论文

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Zhijian Tao, Yunlong Zhou, Jinjian Lu, Wenhu Duan,* Yuxin Qin, Xinxia He，Liping Lin and Jian Ding. Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a gambogic acid derivative, in human leukemia HL-60 cells. Cancer Biology and Therapy 2007, 6 (5), e1～e6. Shilei Zhang, Wenhu Duan,* and Wei Wang.* Efficient, enantioselective organocatalytic synthesis of trichostatin A. Advanced Synthesis & Catalysis 2006, 348, 1228-1234. Fan Yang, Yi Chen, Wenhu Duan,* Chao Zhang, Hong Zhu and Jian Ding.* SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor. International Journal of Cancer 2006, 119, 1184–1193. Jiangang Zhang, Qun Lu, Wenhu Duan, Juncao Cai. New Asymmetric Syntheses of Alkannin and Shikonin. Chinese Chemical Letters, 2005, 16(4),465-467. Jiangang Zhang, Wenhu Duan and Junchao Cai. Asymmetric synthesis of 3(S),17-dihydroxytanshinone. Tetrahedron 2004, 60, 1665-1669. Mu-Yong Kim, Wenhu Duan, Mary Gleason-Guzman, and Laurence H. Hurley. Design, Synthesis, and Biological Evaluation of a Series of Fluoroquinoanthroxazines with Contrasting Dual Mechanisms of Action against Topoisomerase II and G-Quadruplexes. Journal of Medicinal Chemistry, 2003, 46(4), 571-83. Qun Lu, Wenhu Duan and Junchao Cai. A facial Synthesis of Shikonin. Chinese Chemical Letter, 2002, 13, 113-4. Qun Lu, Weijun Liu, Jian Ding, Junchao Cai, Wenhu Duan. Shikonin Derivatives: Synthesis and Inhibition of Human Telomerase. Bioorganic & Medicinal Chemistry Letters，2002, 12, 1375-1378. Wenhu Duan, Anupama Rangan, Hariprasad Vankayalapati, Mu-Yong Kim, Qingping Zeng, Daekyu Sun, Haiyong Han, Oleg Yu. Fedoroff, David Nishioka, Sun Young Rha, Elzbieta Izbicka, Daniel D. Von Hoff and Laurence H. Hurley. Design and Synthesis of Fluoroquinophenoxazines That Interact with Human Telomeric G-Quadruplexes and Their Biological Effects. Molecular Cancer Therapeutics, 2001, 1, 103-120. Qun Zhou, Wenhu Duan, Denise Simmons, Oleg Fedorov, Laurence H. Hurley. Design and Synthesis of a Novel DNA-DNA Interstrand Adenine-Guanine Cross-linking Agent. Journal of the American Chemical Society, 2001, 123, 4865-4866.