齐锦生 - 河北医科大学 - 河北医科大学基础医学院

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发表论文情况：发表论文50余篇（SCI论文20余篇，2篇IF5.0，6篇IF3.0）：出版著作情况：撰写专著2部。成果获奖情况："挑战杯"河北省大学生课外学术科技作品竞赛一等奖：薤白对气滞型血管损伤COX-2和iNOS含量及相互作用的影响。承担科研项目情况： 1.国家重点基础研究发展计划(973项目)子课题(编号：2012CB518601)：营卫“由络以通、交会生化”异常与微血管病变相关性及微观病理特征研究。307万元学术骨干 2.国家自然科学基金项目（81470595）：β-羟丁酸抗硝基化干预糖尿病心脏微血管病变的机制。73万元项目负责人 3.国家自然科学基金课题（81070658）：C-肽调控核因子-kappaB及其共激活因子p300防治糖尿病肾病的分子机制。33万元，项目负责人 4.国家自然科学基金项目（81600384）：β-羟丁酸激活claudin-5表达干预糖尿病心脏微血管病变的机制。17万元项目第四主研人 5.河北省自然科学基金项目（H2015206101）：过氧亚硝基导致糖尿病肾病IV型胶原过量生成的表观调控机制。6万元项目负责人 6.河北省自然科学基金资助项目：滋阴益肾胶囊防治糖尿病肾病与清除过氧亚硝基机理研究编号：C2009001092项目负责人5万元 7.河北省科技厅科技攻关计划：滋阴补肾清除过氧亚硝基阴离子机理及其应用编号：07276101D-73第一主研人1万元 8.石家庄市科技局科技攻关计划：滋阴益肾胶囊编号：07120803A课题组长8万元 9.石家庄科技局科技攻关项目：过氧亚硝基阴离子在糖尿病并发症发病中的作用及中药防治机制编号：04146173A第一主研人 10.省教育厅博士基金项目：过氧亚硝基阴离子在糖尿病骨质疏松发病中的作用及丹皮酚的防治机制编号：B2004122第一主研人 11.校博士基金项目：过氧亚硝基阴离子在糖尿病骨质疏松发病中的作用及丹皮酚的防治机制编号：28第一主研人 12.河北省卫生厅医学科学研究重点课题：过氧亚硝基阴离子在骨质疏松发病中的作用及中药防治机制编号：04062第一主研人

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1.ZhongY,GongWJ,GaoXH,LiYN,LiuK,HuYG,QiJS*,Synthesisandevaluationofanovelnanoparticlecarryingurokinaseusedintargetedthrombolysis,JBiomedMaterResA,108(2),193-200,2020 2.WuXL,MiaoDZ,LiuZJ,LiuK,ZhangBN,LiJL,LiY*,QiJS*,β-hydroxybutyrateantagonizesaorticendothelialinjurybypromotinggenerationofVEGFindiabeticrats,TissueandCell,2020,64,101345. 3.JingZhang,RuonanMao,XinyuWang,KunLiu,QiGeng,YijinYu,YanningLi*,JinshengQi*.Targetedinductionofbonemarrowmesenchymalstemcellstohaveeffectivenessondiabeticpancreaticrestoration.InVitroCellDevBiolAnim.2019Jun;55(6):453-461. 4.LiY,LiX,HeK,LiB,LiuK,QiJ*,WangH,WangY,LuoW.C-peptidepreventsNF-κBfromrecruitingp300andbindingtotheinospromoterindiabeticnephropathy.FASEBJ.2018;32(4):2269-2279. 5.YanningLi,YanZhong,WenjianGong,XuehanGao,HuanliQi,KunLiu,JinshengQi*.C-peptidepreventsSMAD3bindingtoαpromoterstoinhibitcollagentypeIVsynthesis.JMOLENDOCRINOL,2018;61(1):1-11.JMolEndocrinol.2018Jul;61(1):47-56. 6.BinLi,YanningLi,KunLiu,XiujuanWang,JinshengQi*,BoyaWang&YuWang.Highglucosedecreasesclaudins-5and-11incardiacmicrovascularendothelialcells:Antagonisticeffectsoftongxinluo.EndocrRes,2017,42(1):15-21. 7.LiuK,WangXJ,LiYN,LiB,QiJS*,ZhangJ,WangY.Tongxinluoreversesthehypoxia-suppressedclaudin-9incardiacmicrovascularendothelialcells.ChinMedJ(Engl),2016,129(4):442-447. 8.LiY,ZongY,XiaoZ,ZhuM,XiaoH,QiJ*,LiuK,WangH.Developmentalstage-specificembryonicinductionofHepG2celldifferentiation.DigDisSci,2016,61(4):1098-106. 9.YanningLi,ZhigangXiao,BinLi,KunLiu,HuiWang,JinshengQi*,YuWang.Ginsenosideexhibitsconcentration-dependentdualeffectsonHepG2cellproliferationviaregulationofc-MycandHNF-4α.EurJPharm,2016,792:26-32. 10.XiujuanWang,KunLiu,BinLi,YanningLi,KaiweiYe,JinshengQi*,YuWang.Macrophagesaggravatehypoxia-inducedcardiacmicrovascularendothelialcellinjuryviaperoxynitrite:protectionbyTongxinluo.CellCommunAdhes,2015,22(2-6):39-47. 11.LiY,LiuD,ZongY,QiJ,LiB,LiuK,XiaoH.Developmentalstage-specifichepatocytesinducematurationofHepG2cellsbyrebuildingtheregulatorycircuit.MolMed.2015,21:285-95. 12.LiYN,WangXJ,LiB,LiuK,QiJS,LiuBH,TianY.TongxinluoInhibitsCyclooxygenase-2,InducibleNitricOxideSynthase,Hypoxia-inducibleFactor-2α/VascularEndothelialGrowthFactortoAntagonizeInjuryinHypoxia-stimulatedCardiacMicrovascularEndothelialCells.ChinMedJ(Engl).2015,128(8):1114-1120. 13.YanningLi,DemeiLiu,YuanLiu,EnLi,HuiWang,KunLiu,JinshengQi*.ProteinnitrationpromotesinduciblenitricoxidesynthasetranscriptionmediatedbyNF-κBinhighglucose-stimulatedhumanlensepithelialcells.MolCellEndocrinol.2013;370(1-2):78-86. 14.JinhaiJia,YuanLiu,XiaolinZhang,XinkeLiu,andJinshengQi*.RegulationofiNOSexpressionbyNF-κBinhumanlensepithelialcellstreatedwithhighlevelsofglucose.InvestOphthalmolVisSci.2013;54(7):5070-7. 15.YanningLi,MingmingZhao,BinLi,JinshengQi*.DynamiclocalizationandfunctionalimplicationsofC-peptidemightforsuppressionofiNOSinhighglucose-stimulatedratmesangialcells.MolCellEndocrinol.2013;381(1-2):255-60. 16.YanningLi,YanhongZong,JinshengQi*,KunLiu.PrebioticsandOxidativeStressinConstipatedRats,JournalofPediatricGastroenterologyandNutrition,2011,53(4):447-452. 17.YanningLi,JinshengQi*,KunLiu,BinLi,HuiWang,andJinhaiJia.Peroxynitrite-Inducednitrationofcyclooxygenase-2andinduciblenitricoxidesynthasepromotestheirbindingindiabeticangiopathy.MolecularMedicine,2010;16(9-10):335-342. 18.LiangJH,LiYN,QiJS*,JiaXX.Peroxynitrite-inducedproteinnitrationisresponsibleforrenalmitochondrialdamageindiabeticrat.Journalofendocrinologyinvestigation,2010;33(3):140-146. 19.HuiXiao,YanningLi,JinshengQi*,HuiWang,andKunLiu.Peroxynitriteplaysakeyroleinglomerularlesionofdiabeticrat.Journalofnephrology,2009,22(6):800-808. 20.JinshengQi,YanningLi,BingshanZhang,TaoNiuandJinhuanLiang.Peroxynitritemediateshighglucose-inducedosteoblastapoptosis.Journalofendocrinologyinvestigation,2008,31(4):314-320. 21.Xiang-YuRen,Yan-NingLi,Jin-ShengQi*,TaoNiu.Peroxynitrite-inducedproteinnitrationcontributestolivermitochondrialdamageindiabeticrats.Journalofdiabetesanditscomplications,2008,22(5):357-364. 22.Yan-NingLi,Yi-LingWu,Zhen-HuaJia,Jin-ShengQi*.InteractionbetweenCOX-2andiNOSaggravatesvascularlesionandantagonisticeffectofginsenoside.Journalofethnopharmacology,2008,119(2):305-311. 23.Yan-NingLi,Jin-ShengQi*.Interactionsbetweencyclooxygenase-2andinduciblenitricoxidesynthase:anewprospectforintervention.U.S.Chinesejournaloflymphologyandoncology,2008,7(3-4):53-57.

学术兼职

教育部“长江学者”评审专家，国家自然科学基金，医学科学领域，地区、青年、面上项目评审专家。