个人简介

M.S., 1967, Ph.D., 1969, Weizmann Institute, Israel B.S., 1966, Technion, Haifa, Israel

研究领域

Theoretical Chemistry and Biophysics

Professor Warshel's research covers a wide range of problems in modern biophysical chemistry. He and his coworkers have pioneered several of the most effective models for computer simulations of biological molecule.

近期论文

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Computer Simulation of Protein Folding, A. Warshel, and M. Levitt, Nature, 253, 694 (1975). Bicycle-Pedal Model for the First Step in the Vision Process, A. Warshel, Nature, 260, 679-683 (1976). Theoretical Studies of Enzymatic Reactions: Dielectric Electrostatic and Steric Stabilization of the Carbonium Ion in the Reaction of Lysozyme, A. Warshel, and Levitt, J. Mol. Biol., 103, 227 (1976). Computer Modeling of Chemical Reactions in Enzymes and Solution, A. Warshel, John Wiley & Sons: New York (1989). Computer Simulations of Electron Transfer Reactions in Solution and Photosynthetic Reaction Centers, A. Warshel, and W.W. Parson, Ann. Rev. Phys. Chem., 42, 279 (1991). Simulation of Enzyme Reactions Using Valence Bond Force Fields and Other Hybrid Quantum/Classical Approaches, J. aqvist, and A. Warshel, Chem. Rev., 93, 2523 (1993). How Important are Quantum Mechanical Nuclear Motions in Enzyme Catalysis?, J.-K. Hwang, and A. Warshel, J. Am. Chem. Soc., 118, 11745 (1996). Electrostatic Origin of the Catalytic Power of Enzymes and the Role of Preorganized Active Sites, A. Warshel, Mini Review, J. Biol. Chem., 273, 27035-27038 (1998). How Important are Entropic Contributions to Enzyme Catalysis?, A. Warshel, J. Villa, M. Strajbl, T.M. Glennon, Y.Y. Sham, and Z.T. Chu, Proc. Natl. Acad. Sci. USA, 27, 11800-11904 (2001). Dynamics of Biochemical and Biophysical Reactions: Insight from Computer Simulations, A. Warshel and W.W. Parson, Quart. Rev. Biophys., 34, 563-679 (2001). Computer Simulations of Enzyme Catalysis: Methods, Progress and Insights, A. Warshel, Ann. Rev. of Biophysics and Biomolecular Structure, 32, 425-443 (2003). Exploring the Origin of the Ion Selectivity of the KcsA Potassium Channel, A. Burykin, M. Kato and A. Warshel, Proteins: Structure, Function and Genetics, 52, 412-426 (2003). What Really Prevents Proton Transport Through Aquaporin? Charge Self-Energy vs. Proton Wire Proposals, A. Burykin and A. Warshel, Biophys. J., 85, 3696-3706 (2003). Why Does the Ras Switch "Break" by Oncogenic Mutations? A. Shurki, A. Warshel, Proteins: Struct., Funct. Genet., 55, 1-10 (2004). Computer Simulations of Protein Functions: Searching for the Molecular Origin of the Replication Fidelity of DNA Polymerases, J. Florian, M.F. Goodman, and A. Warshel, Proc. Natl. Acad. Sci. USA, 102, 6819-6824 (2005). Electrostatic Basis of Enzyme Catalysis, A. Warshel, P. K. Sharma, M. Kato, Y. Xiang, H. Liu, and M.H.M. Olsson, Chem. Rev., 106, 3210-3235 (2006). Modeling Electrostatic Effects in Proteins, A. Warshel, P. K. Sharma, M. Kato, and W.W. Parson, Biochim. Biophys. Acta, 1764, 1647-1676 (2006). On the Relationship between Thermal Stability and Catalytic Power of Enzymes, M. Roca, H. Liu, B. Messer, and A Warshel, Biochemistry, 46, 15076-15088 (2007). Predicting Drug-Resistant Mutations of HIV Protease, H. Ishikita and A. Warshel, Angew. Chem. Int. Ed., 47, 697-700 (2008).