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研究领域

有机膦催化和廉价金属催化的方法学及其在生物化学中的应用;药物分子的设计与合成。

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Nazarov Cyclization of 1,4-Pentadien-3-ols: Preparation of Cyclopenta[b]indoles and Spiro[indene-1,4′-quinoline]s, Wang, Z.(王治明) *, Xu, X.; Gu, Z.; Feng, W.; Qian, H.; Li, Z.; Sun, X. and Kwon, O.*Chem. Commun.2016, 52, 2811-2814. Multicomponent Copolycondensates via the Simultaneous Hantzsch and Biginelli Reactions, Wu, H.; Fu, C.; Zhao, Y.; Yang, B.; Wei, Y.; Wang, Z.(王治明)* and Tao, L. ACS Macro Lett.2015, 4, 1189-1193. Iron oxide-silver magnetic nanoparticles as simple heterogeneous catalysts for the direct inter/intramolecular nucleophilic substitution of p-activated alcohols with electron-deficient amines, Xu, X.; Wu, H.; Li, Z.; Sun, X. and Wang, Z.(王治明)*Tetrahedron2015, 71, 5254-5259. Phosphine catalysis of allenes with electrophiles, Wang, Z. (王治明); Xu, X. and Kwon, O.*Chem. Soc. Rev.2014, 43, 2927-2940. Nucleophilic Phosphine Organocatalysis: a Practical Synthetic Strategy for the Drug-Like Nitrogen Heterocyclic Framework Construction, Wang, Y.; Pan, J.; Chen, Z.; Sun, X. and Wang, Z.(王治明)*Mini-Rev. Med. Chem.2013, 13, 836-844. FeCl3·6H2O Catalyzed Intramolecular Allylic Amination: Synthesis of Substituted Dihydroquinolines and Quinolines, Wang, Z.(王治明) *; Li, S.; Yu, B.; Wu, H.; Wang, Y. and Sun, X.*J. Org. Chem.2012, 77, 8615-8620. Metal-Free Synthesis of Allylic Amines by Cross-Dehydrogenative-Coupling of 1,3-Diarylpropenes with Anilines and Amides under Mild Conditions, Wang, Z.(王治明); Mo, H.; Cheng, D. and Bao, W.*Org. Biomol. Chem.2012, 77, 4249-4255. An Effective Synthesis of Indazolo[2,1-a]indazole-6,12-diones by Regioselective Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process, Wang, Z. (王治明);Yu, B.; Yuan, C.; Sun, X.* and Bao, W.*Chin. J. Chem.2011, 29, 2769-2774. Copper-Catalyzed Cascade Acylation/Coupling Cyclization Process for the Synthesis of Polycyclic Fused Imidazo[2,1-b][1,3]thiazinones, Wang, Z. (王治明);Yu, B.; Zhang, X.; Sun, X.*; Bao, W.*Chin. J. Chem.2011, 29, 2775-2780. Diversity through a Branched Reaction Pathway: Generation of Multicyclic Scaffolds and Identification of AntiMigratory Agents, Wang, Z.(王治明); Castellano, S.; Kinderman, S. S.; Argueta, C. E.; Beshir, A. B.; Fenteany, G. and Kwon, O.*Chem. Eur. J., 2011, 17, 649-654. Diversity through phosphine catalysis: Octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity,Daniel, C.; Wang, Z.(王治明); Kibbie, J.; Modlin, R.; Kwon, O.*Proc. Nat. Acad. Sci. U.S.A. (PNAS), 2011, 108, 6769-6774(共同第一作者,有机合成部分第一完成人).

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