Wang, Clay C. - University of Southern California

个人简介

Dr. Clay Wang is a Professor at the USC School of Pharmacy. He also holds a joint appointment in the Department of Chemistry of the Dornsife College of Letters, Arts and Sciences and serves on the executive board of the USC Academic Senate. Dr. Wang received his B.A. in chemistry from Harvard University in 1996 and a Ph.D in chemistry from the California Institute of Technology in 2001. After completing a two- year, postdoctoral fellowship in chemistry and chemical engineering at Stanford University, he joined the faculty in the Department of Pharmaceutical Sciences at USC School of Pharmacy as an Assistant Professor in 2003. His research program focuses on the interface of chemistry and biological sciences. Specifically he is exploring the mechanism of natural product biosynthesis in bacteria and fungi. His lab has been studying the use of Aspergillus nidulans as a general host for the production of fungal natural products. Additionally, the lab is interested in designing chemical probes to study gene regulation. The lab is funded from a variety of sources including NIGMS, American Cancer Society, NSF, DOE, DOD, NASA, and CASIS.

研究领域

Natural Products Drug Discovery Gene Regulation of Fungal Secondary Metabolism Metabolic Engineering

The primary focus of my lab is to use an interdisciplinary approach to study natural product drugs. We are interested in studying two aspects of natural product drug discovery: 1) development of heterologous hosts for natural product production and 2) discovery of natural products and their biosynthesis pathways in fungal and bacterial genomes. Both of these topics are significant because recent advances in genome sequencing have provided a large amount of sequence information. My research seeks to leverage this information into drug discovery that can ultimately benefit human health.

近期论文

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Wiemann, P., Guo, C. J., Palmer, J. M., Sekonyela, R., Wang, C. C. C. & Keller, N. P. Prototype of an intertwined secondary-metabolite supercluster. - Proc. Natl. Acad. Sci. USA [2013] 110: 17065-17070 PubMed Guo, C.J., Yeh, H.H., Chiang, Y.M., Sanchez, J.F., Chang, S.L, Bruno, K.S. & Wang, C.C.C. Biosynthetic Pathway for Epipolythiodioxopiperaine Acetylaranotin in Aspergillus terreus Revealed by Genome-based Deletion Analysis. Journal of the American Chemical Society, 2013; 135:7205-7213. PubMed Ahuja, M., Chiang, Y.M., Chang S.L., Praseuth, M.B., Entwistle, R., Sanchez, J.F., Lo, H.C., Yeh, H.H., Oakley, B.R. & Wang, C.C.C.* Illuminating the genomic basis for natural product diversity in Aspergillus nidulans: determining the products of all aromatic polyketide synthases. - Journal of the American Chemical Society, [2012] 134: 8212-8221. PubMed Lo, H.C.., Entwistle, R., Guo, C.J.., Manmeet A., Szewczyk, E., Hung J.H. Chiang, Y.M., Oakley, B.R. & Wang C. C. C.* Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids, austinol and dehydroaustinol in Aspergillus nidulans - Journal of the American Chemical Society [2012] 134: 4709-4720. Sanchez, J.F., Somoza, A., Keller, N.P. & Wang C. C. C.* Advances in Aspergillus secondary metabolite research in the post-genomic era. - Nat. Prod. Rep., [2012] 29: 351-371. Yang, M.D., Chiang, Y.M., Higashiyama, R., Asahina, K., Mann, D.A., Mann, J., Wang, C. C. C., and Tsukamoto, H. Rosmarinic acid and baicalin epigenetically de-repress Pparγ in hepatic stellate cells for their anti-fibrotic effect - Hepatology [2012] 55:1271-1281. Liu, T., Chiang, Y., Somoza, A., Oakley, B.R. & Wang C. C. C.* Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans - Journal of the American Chemical Society [2011] 31: 13313-13314. Sanchez, J. F., Entwistle, R., Hung, J., Yaegashi, J., Jain, S., Chiang, Y., Wang C. C. C.* & Oakley B. R.* Genome-based deletion analysis uncovers the prenyl-xanthone biosynthesis pathway in Aspergillus nidulans. - Journal of the American Chemical Society [2011] 133: 4010-4017. Watanabe, K., Hotta, K., Nakaya, A., Praseuth, A., Wang, C.C.C., Inada, D., Takahashi, K., Fukushi E., Oguri, H., Oikawa, H., Escherichia coli Allows Efficient Modular Incorporation of Newly Isolated Quinomycin Biosynthetic Enzyme into Echinomycin Biosynthetic Pathway for Rational Design and Synthesis of Potent Antibiotic Unnatural Natural Product. - Journal of the American Chemical Society [2009] 131: 9347-9353. Bok, J. W., Chiang, Y., Szewczyk, E., Reyes-Dominguez, Y., Davidson, A. D., Sanchez, J. F., Lo, H. C. Watanabe, K., Strauss, J., Oakley B. R., Wang C. C. C.*, & Keller N. P.* Chromatin-level regulation of cryptic biosynthetic gene clusters in Aspergillus nidulans. - Nature Chemical Biology [2009] 5: 462-464. Chiang, Y., Szewczyk, E., Davidson, A. D., Keller, N. P., Oakley, B. R.*, & Wang, C. C. C.* A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans - Journal of the American Chemical Society [2009] 131: 2965-2970. Watanabe, K., Hotta, K., Praseuth, A. P., Koketsu K., Migita A., Boddy C. N., Wang, C. C. C., Oguri H., & Oikawa H. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. - Nature Chemical Biology [2006] 2: 398-400.