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心脑血管疾病防治;中药与复方药效物质及其配伍原理和药效机制的研究

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1、Synergism and mechanism of Astragaloside IV combined with Ginsenoside Rg1 against autophagic injury of PC12 cells induced by oxygen glucose deprivation/reoxygenation. Biomedicine & Pharmacotherapy,2017,89:124-134(SCI,第1); 2、Effects of Astragalus Combined with Angelica on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice. Biological & Pharmaceutical Bulletin,2017,40(5):598-609(SCI,通讯); 3、Effects of the combination of the main active components of Astragalus and Panax notoginseng on inflammation and apoptosis of nerve cell after cerebral ischemia-reperfusion. The American Journal of Chinese Medicine, 2015, 43(7):1419-38(SCI,第1); 4、Effects of the main active components combinations ofAstragalusandPanax notoginsengon energy metabolism in brain tissues after cerebral ischemia-reperfusion in mice. Pharmacognosy Magazine,2015,11(44):732-9(SCI,第1); 5、Effects of Astragaloside Ⅳ combined with the active components of Panax notoginseng on oxidative stress injury and Nrf2/HO-1 signaling pathway after cerebral ischemia-reperfusion in mice. Pharmacognosy Magazine,2014,10(40):402-9(SCI,第1); 6、Combination between total Astragalus extract and total Panax Notoginseng Saponins strengthened the protective effects on brain damage through improving energy metabolism and inhibiting apoptosis after cerebral ischemia-reperfusion in mice. Chinese Journal of Integrative Medicine,2017,23(6):445-52(SCI,第1); 7、Autophagy in cerebral ischemia and the effects of traditional Chinese medicine.J Integr Med,2015(CSCD,第1) 8. Astragalus extract alleviates nerve injury after cerebral ischemia by improving energy metabolism and inhibiting apoptosis. Biol Pharm Bull, 2012, 35(4): 449-454. (SCI收录) 9、黄芪甲苷和三七总皂苷配伍抗大鼠脑缺血再灌注损伤及其药动学的研究.中国中药杂志,2017,42(19):3786-94CSCD,并列通讯); 10、黄芪甲苷与人参皂苷Rg1配伍抗PC12细胞氧糖剥夺/复糖复氧后自噬性损伤相互作用的研究. 中国药理学通报, 2017, 33(2):235-43(CSCD,并列通讯); 11、人参皂苷Rg1抗PC12细胞氧糖剥夺复糖复氧后损伤与自噬关系的研究.中华中医药杂志, 2017, 32(5):1974-78(CSCD,第1); 12、黄芪甲苷与人参皂苷Rg1配伍对PC12细胞氧糖剥夺复糖复氧后细胞自噬和PI3K信号通路的影响.中国病理生理杂志, 2016, 2(11): 2003-9(CSCD,通讯); 13、自噬在脑缺血性损伤中的作用.中国药理学通报,2015,31(8):1048-52(CSCD,通讯); 14、黄芪和三七的主要有效成分配伍对脑缺血再灌注小鼠NF-κB信号通路及炎性因子表达的影响.中国药理学通报,2015,31(1):141-6(CSCD,第1); 15、黄芪和当归配伍对环磷酰胺所致骨髓造血功能抑制小鼠造血功能的影响.中草药,2017,48(1):121-8.(CSCD,第1); 16、黄芪甲苷与三七有效成分配伍对小鼠脑缺血再灌注后神经细胞凋亡和内质网应激的影响.中草药,2015,46(15):2257-64(CSCD,第1); 17、黄芪甲苷和三七的主要有效成分配伍对小鼠脑缺血再灌注后脑组织能量代谢的影响.中草药,2014,45(2):220-6(CSCD,第1); 18、黄芪和三七4种有效成分配伍对小鼠脑缺血再灌注早期抗氧化应激物质活性的影响.中华中医药杂志,2014,29(6):1940-3(CSCD,通讯); 19、人参皂苷 Rg1 对小鼠脑缺血再灌注后脑组织损伤及 Nrf2/HO-1 途径的影响.中国病理生理杂志,2013, 29(11):2066-71(CSCD,通讯); 20、黄芪甲苷和三七的三种有效成分配伍对小鼠脑缺血/再灌注后氧化应激和Nrf2/HO-1途径的影响.中国药理学通报, 2013, 29(11): 1596-601(CSCD,第1);

学术兼职

湖南省医学会理事、湖南省病理生理学会理事、湖南省神经科学会理事、湖南省病理生理学会中西医结合专业委员会委员、湖南省生理科学会临床生理专业委员会青年委员。为国家自然科学基金(NSFC)评审专家

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