个人简介

MD | Medicine | University of Michigan Medical School 2000 PhD | Organic Chemistry | Northwestern University 1989 BA | Chemistry | Grinnell College 1984

研究领域

Fungal Cell Wall Biology and High Throughput Screening for Antifungal Drugs.

Dr. Krysan's research focuses on two broad areas: 1) antifungal and antibiotic drug discovery and 2) fungal pathogenesis.

近期论文

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2014 Nov 20 Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. "Unraveling the biology of a fungal meningitis pathogen using chemical genetics." Cell. 2014 Nov 20; 159(5):1168-87. 2014 Oct 23 Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. "Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus." Journal of medicinal chemistry. 2014 Oct 23; 57(20):8540-62. Epub 2014 Oct 06. 2014 Jun Krysan DJ, Sutterwala FS, Wellington M. "Catching fire: Candida albicans, macrophages, and pyroptosis." PLoS pathogens. 2014 Jun; 10(6):e1004139. Epub 2014 Jun 26. 2014 May Falsetta ML, Klein MI, Colonne PM, Scott-Anne K, Gregoire S, Pai CH, Gonzalez M, Watson G, Krysan DJ, Bowen WH, Koo H. "Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo." Infection and immunity. 2014 May; 82(5):1968-81. Epub 2014 Feb 24. 2014 May Roemer T, Krysan DJ. "Antifungal drug development: challenges, unmet clinical needs, and new approaches." Cold Spring Harbor perspectives in medicine. 2014 May; 4(5)Epub 2014 May 01.