个人简介
1984年至1988就读于南京大学生物系，获学士学位。1992至1997年就读于美国迈阿密大学医学院生物化学与分子生物学系，获博士学位。1998年至2001年在美国普林斯顿大学分子生物学系接受博士后训练。2001年9月受聘于生物化学与细胞生物学研究所，任研究员，博士生导师，2002年2月至2007年1月，任中国科学院与德国马普学会合作的青年科学家小组组长
研究领域
实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。真核细胞中的染色质分为常染色质和异染色质，处于常染色质区的基因表达活跃，而处于异染色质区的基因保持沉默。由于异染色质会扩展，常、异染色质之间会形成特异的“边界”。该边界的形成既有特异的DNA元件，也有染色质的修饰因子参与。在酿酒酵母中，位于染色体末端的端粒是研究染色质结构/功能、沉默、染色质边界形成/调节、以及DNA复制/重组等表观遗传调控的很好的模型。端粒是由简单的DNA重复序列及其结合蛋白组成。端粒对于维持染色体的稳定性，维持细胞连续分裂和防止细胞衰老具有非常重要的作用。在大多数真核生物中，端粒DNA是由特异性的反转录酶、即端粒酶合成的，在端粒酶缺失的情况下也可以由同源的重组途径合成。另外，端粒也是一种典型的异染色质结构，能抑制相邻的基因表达
近期论文
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Yang-Yang Shao, Ning Lu, Zhen-Fang Wu, Chen Cai, Shan-Shan Wang, Ling-Li Zhang, Fan Zhou, Shi-Jun Xiao, Lin Liu, Xiao-Fei Zeng, Hua-Jun Zheng, Chen Yang, Zhi-Hu Zhao, Guo-Ping Zhao*, Jin-Qiu Zhou*, Xiao-Li Xue* & Zhong-Jun Qin*. (2018) Creating a functional single-chromosome yeast. Nature doi.org/10.1038/s41586-018-0382-x
Ying-Ying Liu, Ming-Hong He, Jia-Cheng Liu, Yi-Si Lu, Jing Peng, Jin-Qiu Zhou*. (2018) Yeast KEOPS complex regulates telomere length independently of its t6A modification function. Journal of Genetics and Genomics 45(5): 247-257
Zhen Zhou, Yu-Ting Liu, Li Ma, Ting Gong, Ya-nan Hu, Hong-Tao Li, Chen Cai Ling-Li Zhang, Gang Wei and Jin-Qiu Zhou*. (2017) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription. eLife 6:e30178 DOI: 10.7554/eLife.30178
Xiaoguang Liu, Wei Wei1, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X Du, Yingming Zhao, Ming Lei, Jin-Qiu Zhou, Jiwen Li* and Jiemin Wong* (2017) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300. Cell Discovery 3, 17016
翻译著作:《抗衰老革命》,周金秋等译,“上海科学技术出版社”发行(ISBN 978-7-5478-3588-3),原著《The Telomerase Revolution》(原著作者:Michael Fossel,出版商:BenBella Books Inc.)
Zhenfang Wu, Jun Liu, Qiong-Di Zhang, De-Kang Lv, Nian-Feng Wu and Jin-Qiu Zhou*. (2017) Rad6–Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. Nucleic Acids Research 45(6):3308-3322
Jun Liu, Ming-Hong He, Jing Peng, Yi-Min Duan, Yi-Si Lu, Zhenfang Wu , Ting Gong, Hong-Tao Li, Jin-Qiu Zhou*. (2016) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast. Aging 8(11): 2827-2847
Yi-Min Duan, Bo-O Zhou, Jing Peng, Xia-Jing Tong, Qiong-Di Zhang and Jin-Qiu Zhou*. (2016) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast. Journal of Genetics and Genomics 43(7): 451-465
细胞端粒藏着长寿的秘密（《人民日报》“科技大观”版）（科普文章），刘军，周金秋，《人民日报》， 2015年5月4日，22 版
Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen*, Jin-Qiu Zhou*. (2015) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochemical Journal 467(3):507-515
Jing Peng, Ming-Hong He, Yi-Ming Duan, Yu-Ting Liu, Jin-Qiu Zhou*. (2015) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity. PloS Genetics 11(3):e1005071
Fu XH, Duan YM, Liu YT, Cai C, Meng FL, Zhou JQ. (2014) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors, PloS One, 2014, 9(3):e90644.
Hu Y, Tang HB, Liu NN, Tong XJ, Dang W, Duan YM, Fu XH, Zhang Y, Peng J, Meng FL, Zhou JQ. (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators, PloS Genet., 9(1):e1003208.
Li QJ, Tong XJ, Duan YM, Zhou JQ. (2013) Characterization of the intramolecular G-quadruplex promoting activity of Est1, FEBS Lett, 587(6):659-65.
Peng J and Zhou JQ (2012) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Res. 40: 581-593
Zhou BO and Zhou JQ (2011) Recent transcription-induced histone H3K4 methylation inhibits gene reactivation. J. Biol. Chem. 286: 34770-776
Wang SS, Zhou BO and Zhou JQ (2011) Histone H3 Lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter. Mol. Cell. Biol. 31: 3171-81
Tong XJ, Li QJ, Duan YM, Liu NN, Zhang ML and Zhou JQ (2011) Est1 protects telomeres and inhibits subtelomeric Y’-element recombination. Mol. Cell. Biol. 31(6): 1263-1274
Zhou BO, Wang SS, Zhang Y, Fu XH, Dang W, Lenzmeier BA and Zhou JQ (2011) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae. PLoS Genet. 7: e1001272
Zhou BO, Wang SS, Xu LX, Meng FL, Xuan YJ, Duan YM, Wang JY, Hu H, Dong XC, Ding JP and Zhou JQ (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol. Cell. Biol. 30: 2391-2400
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