朱学良 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

1985年毕业于中国科技大学生物系，1988年在该校获硕士学位并留校任教。1990年底赴美，以联合培养方式先后在加州大学圣地亚哥分校和德州大学圣安东尼奥健康科学中心完成博士论文，1994年底回到中国科大，1995年在中科院上海细胞所获博士学位。同年成为中科院上海生命科学研究中心的博士后并任课题组长。1997年被聘为研究组长，副研究员，1999年晋升研究员，博士生导师，同年转入中科院上海生命科学研究院生化与细胞所。 2001年获国家“杰出青年基金”支持，国家基金委“创新研究群体”学术带头人、科技部“重大研究计划”首席科学家。历任所长助理、副所长、所学术委员会主任、所学位委员会主席、中科院分子细胞生物学重点实验室主任、中国细胞生物学会副理事长等职。现任Mol Biol Cell和《细胞生物学杂志》副主编、Cell Res编委、Faculty of 1000的Faculty成员、中国细胞生物学会监事等。

研究领域

细胞周期与细胞运动都是生命最基本的活动。细胞周期的目的即是通过细胞分裂完成遗传物质的均等分离和细胞质的分割，实现细胞的增殖。而细胞分裂、迁移、纤毛运动、胞内运输等细胞运动形式以其重要、复杂、动态和完美展现出强烈的吸引力。我们利用分子生物学、细胞生物学和发育生物学的多种技术和手段，以及细胞、斑马鱼、小鼠等系统深入探讨细胞运动的结构基础、分子调节机理，及其与干细胞维持、分化和疾病的关系。其中涉及细胞骨架、分子马达、中心粒、动粒和纤毛等细胞结构和组分，以及物质运输、信号转导、基因表达、蛋白质修饰和相互作用等过程

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xiao Y, Chen J, Wan Y, Gao Q, Jing N, Zheng Y and Zhu X* (2019). Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14. Cell Discov 5:37. Zhao H, Chen Q, Fang C, Huang Q, Zhou J, Yan X* and Zhu X* (2019). Parental centrioles are dispensable for deuterosome formation and function during basal body amplification. EMBO Reports 20(4). pii: e46735. Zheng J, Liu H, Zhu L, Chen Y, Zhao H, Zhang W, Li F, Xie L, Yan X* and Zhu X*(2019). Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation. J Mol Cell Biol 11(1):67-77. Zhang Y, Chen Y, Zheng J, Wang J, Duan S, Zhang W, Yan X* and Zhu X* (2019). Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat. J Mol Cell Biol 11(5):383-394. Li G, Huang S, Yang S, Wang J, Cao J, Czajkowsky D, Shao Z, and Zhu X* (2018). abLIM1 constructs non-erythroid cortical actin networks to prevent mechanical tension-induced blebbing. Cell Discov 4:42. Zhu L, Liu H, Chen Y, Yan X*, and Zhu X* (2018). Rsph9 is critical for ciliary radial spoke assembly and central pair microtubule stability. Biol Cell 111(2): 29-38. Yu F, Guo S, Li T, Ran J, Zhao W, Li D, Liu M, Yan X, Yang X, Zhu X, and Zhou J* (2018). Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res 29(2):171-173. Huang Y, Li T#, Ems‑McClung S, Walczak C, Prigent C, Zhu X, Zhang X, and Zheng Y* (2018).Aurora A activation in mitosis promoted by BuGZ. J Cell Biol 217(1):107-116. Yan X, Zhao H and Zhu X*(2016). Production of Basal Bodies in bulk for dense multicilia formation. F1000 Research 5(F1000 Faculty Rev):1533 (doi: 10.12688/f1000research.8469.1). Review Yan X and Zhu X* (2016).PP2A in meiotic oocytes. Cell Cycle 15(15):1950-1951. Review Zeng L, Cai C, Li S, Wang W, Li Y, Chen J, Zhu X*, Zeng YA* (2016). Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells. PLoS Genet. 12(5): e1006055. Jiang H, He X, Feng D, Zhu X*, Zheng Y*(2015). RanGTP aids anaphase entry through Ubr5-mediated protein turnover. J Cell Biol. 211(1):7-18. Jiang H, Wang S, Huang Y, He X, Cui Hong, Zhu X*, and Zheng Y* (2015). Phase transitions of spindle-associated protein regulate spindle apparatus assembly Cell. 163(1):108-22. Wan Y, Zheng X, Chen H, Guo Y, Jiang H, He X, Zhu X*, and Zheng Y*(2015). Splicing function of mitotic regulators links R-loop–mediated DNA damage to tumor cell killing. J Cell Biol. 209(2), 235-46. Xu Y, Cao L, Huang S, Feng D, Zhang W, Zhu X* and Yan X* (2015). Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. PLoS ONE. 10(4):e0124378. Jiang H, He X, Wang S, Jia J, Wan Y, Wang Y, Zeng R, Yates III J, Zhu X*, and Zheng Y* (2014). A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. Dev Cell. 28(3):268-281. Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X* and Zhu X*(2013). The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol. 15(12):1434-44. Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H,and Zhu X* (2013). The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 288(42):30087-93. Zhou Y, Li S, Huang Q, Xie L, Zhu X* (2013). Nanog suppresses cell migration by downregulating thymosin beta 4 and Rnd3. J Mol Cell Biol. 5(4):239-49. Yan X and Zhu X* (2013). Branched F-actin as a negative regulator of cilia formation. Exp Cell Res. 319(2):147-151