栗占国 - 北京前沿交叉学科研究院 -

研究领域

长期从事风湿免疫病发病机制研究及临床诊治，主要研究方向：（1）类风湿关节炎、红斑狼疮及干燥综合征等自身免疫病致病抗原、免疫细胞及其致病机制；（2）自身免疫病分子标志物筛选及早期诊断方法的建立；（3）从新型炎症因子、免疫负调控，探讨自身免疫病的新型免疫干预方法。

近期论文

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1. He J; Zhang X; Wei YB; Sun XL; Chen YP; Deng J; Jin YB; Gan YZ; Hu X; Jia RL; Xu CH; Hou ZH; Leong YA; Zhu L; Feng JH; An Y; Jia Y; Li C; Liu X; Ye H; Ren LM; Li R; Yao HH; Li YH ; Chen S; Zhang XW; Su Y; Guo JP; Shen N; Morand EF; Yu D; Li ZG, Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus, Nature Medicine, 22(9)(2016), 991-993. 2. Chen XJ; Sun XL; Yang W; Yang B; Zhao XZ; Chen ST; He LL; Chen H; Yang CM; Xiao L; Chang Z; Guo JP; He J; Zhang FP; Zheng F; Hu ZB; Yang ZY; Lou JZ; Zheng WJ; Qi H; Xu CQ; Zhang H; Shan HY; Zhou XJ; Wang QW; Shi Y; Lai LH; Li ZG; Liu WL, An autoimmune disease variant of IgG1 modulates B cell activation and differentiation, Science , 362(6415) (2018),700-705. 3. Liu Y; Mu R; Gao YP; Dong J; Zhu L; Ma YY; Li YH; Zhang HQ; Han D; Zhang Y; McInnes IB; Zhang JG; Shen BF; Yang G; Li ZG, A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases, Cell Host & Microbe, 19(3)(2016), 400-408. 4. Li ZG, A new look at rheumatology in China —opportunities and challenges, Nature Reviews Rheumatology, 11(5)(2015), 313. 5. He J; Tsai LM; Leong YA; Hu X; Ma CS; Chevalier N; Sun XL; Vandenberg K; Rockman S; Ding Y; Zhu L; Wei W; Wang CQ; Karnowski A; Belz GT; Ghali JR; Cook MC; Riminton DS; Veillette A; Schwartzberg PL; Mackay F; Brink R; Tangye SG; Vinuesa CG; Mackay CR; Li ZG; Yu D, Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure, Immunity, 39(4)(2013), 770-781. 6. Hu FL, Mu R, Zhu JX, Shi LJ, Li YN, Liu X, Shao WW, Li GY, Li MH, Su Y, Cohen PL, Qiu XY, Li ZG, Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis, Annals of the Rheumatic Diseases, 73(5)(2014), 928-936. 7. Wang T; Sun XL; Zhao J; ZhangJ; Zhu HQ; Li C; Gao N; Jia Y; Xu DK; Huang FP; Li NL; Lu LW; Li ZG, Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood, Annals of the Rheumatic Diseases, 74(6)(2015), 1293-1301. 8. Du, Y., Y. Cui, X. Liu, F. Hu, Y. Yang, X. Wu, X. Ma, X. Zuo, Y. Sheng, J. Xu, P. Zhu, L. Sun, N. Hong, X. Zhang, J. Guo, and Z. Li. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol.2014; 66:822-830.