研究领域
哺乳动物的Mediator Complex是由大约30个蛋白质组成的多蛋白复合体，是介于转录因子与mRNA Polymerase II基础转录机器之间的连接桥梁。几乎所有的基因表达都需要Mediator的调节。主要对Mediator的调控机理及生物学功能作深入研究。取得了一系列研究成果。
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1. X u Yang, Meng Zhao, Min Xia, Yuting Liu, Jun Yan, Hongbin Ji, and Gang Wang*. Selective Requirement for Mediator MED23 in Ras-active Lung Cancer. PNAS. 2012, 109(41): E2813- 22.
2. Jing-wen Yin, Yan Liang, Ji Yeon Park, Dongrui Chen, Xiao Yao, Qi Xiao, Zhen Liu, Bo Jiang, Yu Fu, MenghanBao, Yan Huang, Yuting Liu, Jun Yan, Min sheng Zhu, Zhongzhou Yang, Pingjin Gao, Bin Tian, Dangsheng Li, Gang Wang*. The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes & Dev. 2012, 29 (19).
3. Yan Huang, Wen-cheng Li, Xiao Yao, Qi-jiang Lin, Jing-wen Yin, Yan Liang, Monika Heiner, Bin Tian, Jingyi Hui, and Gang Wang*. Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit. Mol Cell. Cover story with commentary; Highlighted in Faculty 1000. 2012. 45,459-469.
4. Meng Zhao, Xu Yang, Yu Fu, Haifang Wang, Yuanheng Ning, Jun Yan, Ye-Guang Chen, and Gang Wang*. Mediator MED15 modulates transforming growth factor beta (TGFβ)/Smad signaling and breast cancer cell metastasis. JMCB. 2013. 5(1):57-60.
5. Wei Wang, Lu Huang, Yan Huang, Jing-wen Yin, Arnold J. Berk, Jeffrey Friedman, Gang Wang*. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell. 2009. 16, 764-771.
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