个人简介

B.Sc. in Chemistry (cum laude), SUNY Buffalo, 1979 M.S. in Medicinal Chemistry, Kansas University, 1982 Ph.D. in Medicinal Chemistry, Kansas University, 1984 NIH Postdoctoral Fellowship, Yale University, 1984 – 1986

研究领域

Synthetic Organic Chemistry

Research activities in the Panek Group emphasize the area of synthetic organic chemistry, in particular the induction of chirality. The problems under study reflect their general interest in the synthesis of new reagents and development of new reaction methods. Ongoing studies in the area of natural product synthesis generate a complementary research effort. In the synthesis of complex organic molecules, new research methods are employed or developed to carry out the defined objectives. They are also affiliated with the Center for Molecular Discovery.

近期论文

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Total Synthesis of (+)-Isatisine A: Jihoon Lee and James S. Panek. Org. Lett., 2011, 13, 502-505. Stereoselective C-Glycosidations with Achiral and Chiral Allenylsilanes: Ryan A. Brawn and James S. Panek. Org. Lett., 2010, 12, 4624-4627. Total Synthesis of (−)-Virginiamycin M2: Jie Wu and James S. Panek. Angew Chm. Int. Ed., 2010, 49, 6165-6168. Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90. Iwona E. Wrona, Alexander Gozman, Tony Taldone, Gabriela Chiosis and James S. Panek. J. Org. Chem., 2010, 75 (9), 2820–2835. Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si−H Insertion: Jie Wu, Yu Chen and James S. Panek Org. Lett., 2010, 12 (9), 2112–211. Regioselective Intramolecular Dipolar Cycloaddition of Azides and Unsymmetrical Alkynes: Ryan A. Brawn, Morgan Welzel, Jason T. Lowe and James S. Panek. Org. Lett., 2010, 12 (2), 336–339. Synthesis of Reblastatin, Autolytimycin, and Non-Benzoquinone Analogues: Potent Inhibitors of Heat Shock Protein 90 Iwona E. Wrona, Alexander Gozman, Tony Taldone, Gabriela Chiosis and James S. Panek. J. Org. Chem., 2010, 75 (9), 2820–2835. Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si−H Insertion Jie Wu, Yu Chen and James S. Panek. Org. Lett., 2010, 12 (9), 2112–211. Regioselective Intramolecular Dipolar Cycloaddition of Azides and Unsymmetrical Alkynes Ryan A. Brawn, Morgan Welzel, Jason T. Lowe & James S. Panek. Org. Lett., 2010, 12 (2), 336–339. Total Synthesis of Brevisamide. Jihoon Lee and James S. Panek. Org. Lett. 2009, 11, 4390. Synthesis of Enantioenriched Homopropargylic Sulfonamides by a Three Component Reaction of Aldehydes, Sulfonamide, and Chiral Allenylsilanes. Ryan A. Brawn and James S. Panek. Org. Lett. 2009, 11, 4362. Steroocontrolled Synthesis of Spirooxindoles Through Lewis Acid Promoted [5 + 2]-Annulation of Chiral Silylalcohols. Yun Zhang and James S. Panek. Org. Lett. 2009, 11, 3366. Steroocontrolled Synthesis of Spirooxindoles Through Lewis Acid Promoted [5 + 2]-Annulation of Chiral Silylalcohols. Yun Zhang and James S. Panek. Org. Lett. 2009, 11, Submitted for publication. Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on Actin State, Cell Cycle and Tumor Cell Growth. Iwona E. Wrona, Jason T. Lowe, Thomas J. Turbyville, Tanya R. Johnson, Julien Beignet, John A. Beutler, and James S. Panek. J. Org. Chem. 2009, 74, 1897-1916. [3 + 2] Annulation of Enantioenriched Allenylsilanes with In Situ Generated Iminium Ions: Stereoselective Synthesis of Dihydropyrroles and Dihydrooxazines. Ryan Brawn and James S. Panek.. Org. Lett. 2009, 11, 473-476. Total Synthesis of (-)-Kendomycin. Jason T. Lowe, and James S. Panek. Org. Lett. 2008, 9, 3813. Total Synthesis of the HSP-90 Inhibitor Geldanamycin. Hua-Li Qin, James S. Panek. Org. Lett. 2008, 10, 2477. Design and Synthesis of Ansamycin Antibiotics. Iwona E. Wrona, Vangelis Agouridas, James S. Panek. Comptes-Rendus Académie des Sciences, Paris 2008, 11, 1483 – 1522. Total Synthesis and Stereochemical Reassignmant of (+)-Neopeltolide. Willmen Youngsaye, Jason T. Lowe, Frauke Pohlki, Paul Ralifo, and James S. Panek Angew. Chem. Int. Ed. 2007, 46, 9211-9214. Diversity Generation using Alkylidene Indane and Related Scaffolds. Sarathy Kesavan, James S. Panek and John A. Porco. Org. Lett. 2007, 9, 5203-5206.