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研究领域

1.以NMR为主要技术手段研究蛋白质与蛋白质之间的相互作用(以与人类疾病相关的、蛋白质质量控制体系中的关键分子为研究目标); 2.以NMR为主要技术手段研究药物靶标蛋白与有机小分子之间的相互作用; 3.基于NMR代谢组学技术的药理学和毒理学研究。

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Ren, J.#, Li, J.#, Wang, Y.#, Chen, W., Shen, A., Liu, H., Chen, D., Cao, D., Li, Y., Zhang, N.X., Xu, Y., Geng, M.*, He, J.*, Xiong, B.*, Shen, J.*, Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization, Bioorganic & Medicinal Chemistry Letters, 24, 2525–2529, 2014 Liu, X.#, Zhong, F.#, Tang, X.#, Lian, F., Zhou, Q., Guo, S., Liu, J., Sun, P., Hao, X., Lu, Y., Wang, W.*, Chen, N., Zhang, N.X.*, An assessment of the protective effects of Cordyceps sinensis against liver and heart injuries in a rat model of chronic kidney disease, Acta Pharmacologica Sinica, 35, 697-706, 2014 Wen, Y.#, Cui, R.#, Zhang, H.Q., Zhang, N.X.*, 1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of the human deubiquitinase Usp28, Biomolecular NMR Assignments, in press Shi, L., Wen, Y., Zhang, N.X.*, 1H, 13C and 15N backbone and side-chain resonance assignments of the N-terminal ubiquitin-binding domains of USP25, Biomolecular NMR Assignments, in press Liu, X.#, Zhu, W.#, Guan, S., Feng, R., Zhang, H., Liu, Q., Sun, P., Lin, D.H.*, Zhang, N.X.*, Shen, J.*, Metabolomic analysis of anti-hypoxia and anti-anxiety effects of Fu Fang Jin Jing Oral Liquid, PLoS One, 8(10), e78281, 2013 Zhao, L.#, Cao, D.#, Chen, T.#, Wang, Y.#, Miao, Z., Xu, Y., Chen, W., Wang, X., Li, Y., Du, Z., Xiong, B.*, Li, J., Xu, C., Zhang, N.X., He, J.*, Shen, J.*, Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain, Journal of Medicinal Chemistry, 56(10), 3833-51, 2013 任景,李健,石峰,王昕,何建华*,许叶春,张乃霞,熊兵,沈竞康*、基于片段的药物发现方法进展,药学学报,48 (1),14−24,2013 Wang, M., Du, Y., Wang, J.Y., Luo, X.M., Jiang, H.L., Zhang, N.X.*, Xu, Y.C.*, Dynamic behavior of ubiquitin receptor S5a in free and complex with K48-linked diubiquitin, Molecular Simulation, 38(12), 1015–1021, 2012 张乃霞*,吴娟,张华群,刘霞、NMR技术在蛋白质-蛋白质相互作用研究中的应用,波谱学杂志 ,29(2),182-189,2012 (特邀综述) Zhu, J., Tong, X.T., Cao, C.Y., Wu, G., Zhang, N.X., Wu, H.*, Solution structure of BmKalphaTx11, a toxin from the venom of the Chinese scorpion Buthus martensii Karsch, Biochemical and Biophysical Research Communications, 391(1), 627-633, 2010 Zhou, X., Zhang, N.X., Liu, L., Walters, K.J., Hanna, P.E., Wagner, C.R.*, Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190, FEBS Journal, 276(23), 6928-6941, 2009 Zhang, N.X., Walters, K.J.*, Insights into how protein dynamics affects arylamine N-acetyltransferase catalysis, Biochemical and Biophysical Research Communications, 385(3), 395-401, 2009 Zhang, N.X.#, Wang, Q.#, Ehlinger, A.#, Randles, L.#, Lary, J.W., Kang, Y., Haririnia, A., Storaska, A.J., Cole, J.L., Fushman, D., Walters, K.J.*, Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13, Molecular Cell, 35(3), 280-290, 2009

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