个人简介

教育 1988-1991南开大学生物化学硕士学位 1979-1983江西大学微生物学学士学位 工作 1983–1988南昌味精厂助理工程师 1991-至今中国医学科学院北京协和医学院血液学研究所血液病医院实习研究员、助理研究员、副研究员和研究员

研究领域

从事药物药理学的研究工作，主要开展血液系统肿瘤耐药机制及其靶向治疗策略的研究

从事药物药理学的研究工作，主要开展血液系统肿瘤耐药机制及其靶向治疗策略的研究。

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhenzhen Li, Zhou Ye, Xiaolong Zhang, Qing Zhang, Dongmei Fan, Yanjun Zhang, Hongbo R. Luo, Xiangfei Yuan, Zongfang Li, Dongsheng Xiong E1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice Oncotarget, 2016 Jun 17 2. Linlin Jiang, Ming Yang, Xiaoyun Zhang, Shiqi Bao,Li Ma, Dongmei Fan, Yuan Zhou, Dongsheng Xiong, and Yongsu Zhen A novel antibody–drug conjugate anti-CD19(Fab)-LDM in the treatment of B-cell non-Hodgkin lymphoma xenografts with enhanced anticancer activity J Drug Target. 2016 Jan;24(1):47-57 3. Dongmei Fan, Wei Li, Yuqi Yang, Xiaolong Zhang, Qing Zhang, Yan Yan, Ming Yang,Jianxiang Wang1 and Dongsheng Xiong Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patient-derived B-ALL cells J Hematol Oncol. 2015 Oct 6;8(1):108 4. Zhang Y, Liu R, Fan D, Shi R, Yang M, Miao Q, Deng ZQ, Qian J, Zhen Y, Xiong D, Wang J The novel structure make LDM effectively remove CD123+ AML stem cells in combination with interleukin 3 Cancer Biol Ther. 2015 Oct;16(10):1514-25 5. Fan D，Li Z, Zhang X, Yang Y, Yuan X, Zhang X, Yang M, Zhang Y, Xiong D. AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells J Hematol Oncol. 2015 Feb 28;8(1):18 6. Yan C, Yang M, Li Z, Li S, Hu X, Fan D, Zhang Y, Wang J, Xiong D Umbilical Cord-derived Mesenchymal Stem Cells with sTRAIL Gene Expression Driven by AFP Promoter Suppress Orthotopically Implanted Hepatocarcinoma in Mice Biomaterials. 2014 Mar;35(9):3035-43 7. Ren S, She M, Li M, Zhou Q, Liu R, Lu H, Yang C, Xiong D The RNA/DNA-binding protein PSF relocates to cell membrane and contributes cells' sensitivity to antitumor drug, doxorubicin Cytometry A. 2014 Mar;85(3): 231-41 8. Hu Y, Li S, Yang M, Yan C, Fan D, Zhou Y, Zhang Y, Yagüe E, Xiong D Sorcin silencing inhibits epithelial-to-mesenchymal transition and suppresses breast cancer metastasis in vivo Breast Cancer Res Treat. 2014 Jan;143(2):287-99 9. Yuan XF, Peng HW, Ding YH, Yan CH, Zhang YJ, M Yang, Xiong DS. Gene therapy in B-NHL cell line using adenovirus-mediated transfer of secretable trimeric TRAIL gene expression driven by CD20 promoter Exp Hematol. 2013;41(3):221-230 10. Yan C, Li S, Li Z, Peng H, Yuan X, Jiang L, Zhang Y, Fan D, Hu X, Yang M, Xiong D. Human umbilical cord mesenchymal stem cells as vehicles of CD20-specific TRAIL fusion protein delivery: a double-target therapy against non-Hodgkin's lymphoma Mol Pharm. 2013 Jan 7; 10(1):142-151

学术兼职

中国医药生物技术协会单克隆抗体专业委员会委员，天津市药理学会理事，天津市生物医学工程学会理事，天津市细胞生物学会理事，白血病.淋巴瘤杂志编委；国家自然科学基金、国家科学技术奖励、国家中小企业创新基金、中国博士后科学基金和天津市科技发展计划项目评审专家