许元富 - 中国医学科学院血液学研究所 -

个人简介

教育 1996-2000年，中国协和医科大学，药学专业，理学硕士 1988-1992年，南开大学，生物系分子生物学专业，理学学士工作 2013/09-至今，中国医学科学院,血液病医院(血液学研究所)，研究员 2004/09-2013/09，中国医学科学院,血液病医院(血液学研究所)，副研究员 1998/12-2007/06，多次公派香港科技大学生物系，访问学者 1998/03-2004/09，中国医学科学院血液学研究所，助理研究员 1992/09-1998/03，中国医学科学院血液学研究所，实习研究员

研究领域

天然免疫、免疫微环境的调控和炎症因子。近期的研究集中在中性粒细胞死亡的可塑性及功能的调控研究、肿瘤坏死因子及其小分子抑制剂的研究以及移植物抗宿主病(GVHD)的发病机制及干预研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Li Ma#, Chunhua She#, Qian Shi, Qiang Yin, Xinxin Ji, Yongrong Wang, Yulong Fan, Xinyao Kong, Peng Li, Zengfeng Sun, Xiaohui Zhang, Zhen Zhang, Jian Wang, Tong Wang, Yuanfu Xu*, Wenliang Li*. TNFα inhibitor C87 sensitizes EGFRvⅢ transfected glioblastoma cells to gefitinib inhibition by a concurrent blockade of TNFα signaling. Cancer Biology&Medicine, 2019(accepted). Kutay Karatepe#, Haiyan Zhu#, Xiaoyu Zhang#, Rongxia Guo, Hiroto Kambara, Fabien Loison, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, John Manis, Tao Cheng, Fengxia Ma, Yuanfu Xu*, and Hongbo R. Luo*. Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 2018, Nov 13; 11: 1–14. Qingming Hou#, Fei Liu#, Anutosh Chakraborty. Yonghui Jia, Amit Prasad, Hongbo Yu, Li Zhao; Keqiang Ye, Solomon H, Solomon H. Snyder, Yuanfu Xu*, Hongbo R. Luo *. Inhibition of inositol hexakisphosphate kinase 1(IP6K1) enhances host defenses while suppressing neutrophil-mediated pulmonary damage in bacterial pneumonia. Sci Transl Med, 2018 ,4;10(435). Hiroto Kambara #, Fei Liu #, Xiaoyu Zhang #, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou, Leslie E. Silberstein, Tao Cheng, Mingzhe Han, Yuanfu Xu, and Hongbo R. Luo*. Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death. Cell Reports. 2018, 22, 2924–2936.. Bajrami B*, Zhu H*, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HR. G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016; 213(10):1999-2018. Wu Q, Zhang L,Su P, Lei X, Liu X,Wang H, Lu L, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Han M, Xu Y, Wang F, Zhou J*. MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling. Cell Research ,2015; 25:1314–1332. Hyun-Jeong Kwak, Peng Liu, Besnik Bajrami, Yuanfu Xu, Shin-Young Park, Ce´ sar Nombela-Arrieta, Subhanjan Mondal, Yan Sun, Haiyan Zhu,Li Chai, Leslie E. Silberstein, Tao Cheng, and Hongbo R. Luo*. Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis. Immunity. 2015;42(1):159-171. Shannan Cao, Peng Liu, Haiyan Zhu, Haiyan Gong, Jianfeng Yao, Yawei Sun, Guangfeng Geng, Tong Wang, Sizhou Feng, Mingzhe Han, Jiaxi Zhou, Yuanfu Xu*. Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions. PLoS ONE, 2015; 10(9):e0137221. doi:10.1371/journal. pone.0137221 Fabien Loison, Haiyan Zhu, Kutay Karatepe, Anongnard Kasorn, Peng Liu, Keqiang Ye, Jiaxi Zhou, Shannan Cao, Haiyan Gong, Dieter E. Jenne, Eileen Remold-O’Donnell, Yuanfu Xu *, and Hongbo R. Luo *. Proteinase 3-dependant caspase-3 cleavage mediates neutrophil death and inflammation. J Clin Invest. 2014;124(10):4445-58. Li Ma, Haiyan Gong, Haiyan Zhu, Qing Ji, Peng Liu, Shannan Cao, Jianfeng Yao, Pei Shu, Mingzhe Han, Xiaotong Ma, Dongsheng xiong, Hongbo R. Luo,Fei Wang, Jiaxi Zhou* & Yuanfu Xu*. A Novel Small-molecule TNFα Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model. J Bio Chem, 2014;289:12457-12466. Xu Y, Li H, Bajrami B, Kwak H, Cao S, Liu P, Zhou J, Zhou Y, Zhu H, Ye K, Luo HR*. Cigarette smoke(CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. PNAS. 2013;110(19):7726-31. Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J,Wiedmer T, Sims PJ, Wang F*. Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model. Blood.2012; 120(24):4712-9. Yuanfu Xu#, Fabien Loison#, and Hongbo R. Luo* .Neutrophil spontaneous death is mediated by downregulation of autocrine signaling through GPCR,PI3Kγ, ROS, and actin. PNAS.2010;107: 2950–2955. Y Gao, D Xiong, M Yang, H Liu, H Peng, X Shao, Y Xu, C Xu, D Fan, L Qin, C Yang and Z Zhu. Efficient inhibition of multidrug-resistant human tumors with a recombinant bispecific anti-P-glycoprotein x anti-CD3 diabody. Leukemia, 2004; 18, 513–520. Xiong, D., Xu, Y., Liu, H., Peng, H., Shao, X., Lai, Z., Fan D., Yang, M., Han, J., Xie., Y., Yang, C., and Zhu, Z. Efficient inhibition of human B-cell lymphoma xenografts with an anti-CD20 x anti-CD3 bispecific diabody. Cancer Lett., 2002, Mar 8;177(1):29-39. Xu Yuanfu, Yang Chunzheng, Zhu Zhenping,. Bispecific antibody and its clinical applications in cancer. Chinese Science Bulletin 2001;46(5):353-357.