何苏丹 - 中国医学科学院苏州系统医学研究所 -

个人简介

1998年-2002年浙江大学生物学学士 2002年-2008年北京协和医科大学生化与分子生物学博士（期间2004-2008年在美国德州大学西南医学中心学习) 2008年-2010年北京生命科学研究所生物医学博士后 2018年11月至今苏州系统医学研究所研究员

研究领域

主要研究细胞程序性死亡的分子机制及生理学、病理学意义。

近期论文

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1. He S*, Wang X*. RIP kinases as modulators of inflammation and immunity. Nat Immunol. 2018;19(9):912-922. 2. Ma H, Chen Q, Zhu F, Zheng J, Li J, Zhang H, Chen S, Xing H, Luo L, Zheng LT, He S*, Zhang X*. Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor. Eur J Med Chem. 2018;149:110-121. 3. Yang C, Li J, Yu L, Zhang Z, Xu F, Jiang L, Zhou X*, He S*. Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis. Cell Death Dis.2017;8(10):e3084. 4. Cao Z, Peng F, Hu Z, Chu B, Zhong Y, Su Y*, He S*, He Y*.In vitro cellular behaviors and toxicity assays of small-sized fluorescent silicon nanoparticles. Nanoscale. 2017;9 (22):7602-7611. 5. Hou J, Zhang Z, Huang Q, Yan J, Zhang X, Yu X, Tan G, Zheng C, Xu F*, He S*. Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo. BMC Infect Dis. 2017 Mar 20;17(1):217. 6. Hu Z, Song B, Xu L, Zhong Y, Peng F, Ji X, Zhu F, Yang C, Zhou J, Su Y, Chen S, He Y*, He S*. Aqueous synthesized quantum dots interfere with the NF-κB pathway and confer anti-tumor, anti-viral and anti-inflammatory effects. Biomaterials 2016;108:187-196. 7. Yang C, He S*. Heat shock protein 90 regulates necroptosis by modulating multiple signaling effectors. Cell Death Dis 2016;3;7:e2126. 8. He S*, Huang S, Shen Z*. Biomarkers for the detection of necroptosis. Cell Mol Life Sci 2016;73(11-12):2177-81. 9. Dong T, Li C, Wang X, Dian L, Zhang X, Li L, Chen S, Cao R, Li L, Huang N, He S*, Lei X*. Ainsliadimer A selectively inhibits IKKa/b by covalently binding a conserved cysteine. Nat Commun 2015; 27;6:6522. 10. Yu X, Li Y, Chen Q, Su C, Zhang Z, Yang C, Hu Z, Hou J, Zhou J, Gong L, Jiang X, Zheng C*, He S*. Herpes simplex virus Type 1 (HSV-1) and HSV-2 mediate species specific modulations of programmed necrosis through the viral ribonucleotide reductase large subunit R1. J Virol 2015;90(2):1088-95. 11. Wang X, Li Y, Liu S, Yu X, Li L, Shi C, He W, Li J, Xu L, Hu Z, Yu L, Yang Z, Chen Q, Ge L, Zhang Z, Zhou B, Jiang X, Chen S, He S*. Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense. Proc Natl Acad Sci USA 2014;111(43):15438-43. 12. Wang H, Jiang X, Wang X, Wei X, Zhu Y, Sun B, Su Y, He S*, He Y*. A hairpin DNA-assisted silicon/silver based surface enhanced raman scattering platform for ultrahighly sensitive and specific discrimination of deafness mutations in a real system. Anal Chem 2014;86:7368-76. 13. He S*, Liang Y, Shao F, Wang X*. Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3 mediated pathway. Proc Natl Acad Sci USA 2011;108:20054-59. 14. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X*. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009; 137:1100-1111. 15. Liu S, Wang X, Li Y, Xu L, Yu X, Ge L, Li J, Zhu Y*, He S*. Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons. BioMed research international 2014, 2014:290182. 16. Yu X, He S*. The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways. Virol J 2016;6;13(1):77. 17. Zhang Y, Zhang J, Yan R, Tian J, Zhang Y, Zhang J, Chen M, Cui Q, Zhao L, Hu R, Jiang M, Li Z, Ruan C, He S, Dai K*. Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis. Proc Natl Acad Sci USA 2017; 114(11):2964-2969. 18. Liu K, Jian Y, Sun X, Yang C, Gao Z, Zhang Z, Liu X, Li Y, Xu J, Jing Y, Mitani S, He S, Yang C*. Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J Cell Biol. 2016;212(2):181-98. 19. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X*, Wang X*.Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012;148:213-227. 20. Cheng J, Zhu Y, He S, Liu Y, Chen J, Han B, Petrillo M, Wrzeszczynski K, Yang S, Dai P, Zhai S, Han D, Zhang M, Li W, Liu X, Li H, Chen ZY, Yuan H*. Functional mutation of SMAC/DIABLO, Encoding a Mitochondrial Pro-apoptotic Protein, Causes Human Progressive Hearing Loss DFNA64. Am J Hum Genet 2011;89:56-66.