O'Connor, David - 中国医学科学院苏州系统医学研究所 -

个人简介

Qualifications Ph.D., University of Liverpool, 1983 M.Sc., (with Distinction) in Biochemistry, University College London, UK, 1980 B.Sc., (Hons) in Zoology & Biological Chemistry, University of Salford, UK, 1979 Experience Dean, Research & Graduate Studies, XJTLU, (2013 - Now) Professor, Department of Biological Sciences at XJTLU, (2012 - Now) Head, Department of Biological Sciences at XJTLU, (2012 - Now) Acting Head, Department of Environmental Science at XJTLU, (2012 - 2013) Professor and Director, Centre for Proteomic Research, Centre for Biological Sciences, University of Southampton, UK, (2001 - 2012) Reader, School of Biological Sciences, University of Southampton, UK, (2000 - 2001) Senior Lecturer, School of Biological Sciences, University of Southampton, UK, (1995 - 2000) Lecturer, Department of Biochemistry, University of Southampton, UK, (1991 - 1995) Royal Society New Blood Lecturer, Department of Biochemistry, University of Southampton, UK, (1986 - 1991) Royal Society Post-Doctoral Fellow, Department of Medical Biochemistry, University of Geneva Medical School, Switzerland, (1984 - 1986)

研究领域

1. Proteomics – applications and new approaches 2. Molecular microbiology – host-pathogen interactions and survival/stress responses

近期论文

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Erika Parkinson, Pete Boyd, Maja Aleksic, Richard Cubberley, David O'Connor, (2014), Stable isotope labeling method for the investigation of protein haptenation by electrophilic skin sensitizers, Toxicological Sciences, 142 (1), 239-249 E Parkinson, P Skipp, M Aleksic, A Garrow, T Gadd, Hughes, M., Clough, G. and O'Connor, C.D., (2014), Proteomic Analysis of the Human Skin Proteome after in vivo treatment with sodium dodecyl sulphate, PLoS ONE, 9 (5), e97772 B.M. Jones, M.D. Iglesias-Rodriguez, P.J. Skipp, R.J. Edwards, M.J. Greaves, Young, J.R., Elderfield, H. & O'Connor, C.D., (2013), Responses of the Emiliania huxleyi proteome to ocean acidification, PLoS ONE, 8 (4), e61868 C.D. O'Connor, (2012), Beyond the genome, Public Service Review Europe, 24, 340-341 C. Gill, E. Parkinson, M.K. Church, P. Skipp, D. Scott, White, A.J., O'Connor, C.D. & Clough, G.F., (2011), A qualitative and quantitative proteomic study of human microdialysate and the cutaneous response to injury, AAPS J., 13, 309-317 B.M. Jones, R.J. Edwards, P.J. Skipp, C.D. O'Connor, M.D. Iglesias-Rodriguez, (2011), Shotgun proteomic analysis of Emiliania huxleyi, a marine phytoplankton species of major biogeochemical importance, Marine Biotech., 13, 496-504 J.D. Jones, C.D. O'Connor, (2011), Protein acetylation in prokaryotes, Proteomics, 11, 3012-3022 P.J Skipp, C.D. O'Connor, (2011), Shotgun proteomics: future perspective in bioanalysis, Bioanalysis, 3, 2159-2160 K. Gulla, K. Gupta, A. Krarup, P. Gal, W. Schwaeble, Sim, R., O'Connor, C.D., & Hajela, K., (2010), Activation of MBL-associated serine proteases (MASPs) leads to generation of a fibrin clot, Immunology, 129, 482-495 B.L. Nicholas, P. Skipp, S. Barton, D. Singh, D. Bagmane, Mould, R., Angco, G., Ward, J., Guha-Niyogi, B., Wilson, S., Howarth, P., Davies, D.E., Rennard, S., O'Connor, C.D., & Djukanović, R., (2010), Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease, Am. J. Respir. Crit. Care Med., 181, 1049-1060 I. Mary, A. Oliver, P. Skipp, R. Holland, J. Topping, (2010), Metaproteomic and metagenomic analyses of defined oceanic microbial populations using microwave cell fixation and flow cytometric sorting, FEMS Microbiol. Ecology, 74, 10-18 R.A. McDonald, P. Skipp, J. Bennell, C. Potts, L. Thomas, & O'Connor, C.D., (2009), Mining whole-sample mass spectrometry proteomics data for biomarkers, Expert Systems with Applications, 36, 5333-5340 J.N. Williams, P.J. Skipp, C.D. O'Connor, M. Christodoulides, J.E. Heckels, (2009), Immunoproteomic analysis of the development of natural immunity in subjects colonized by Neisseria meningitidis reveals potential vaccine candidates, Infect. Immun., 77, 5080-5089 N.R. Thomson, M.T.G. Holden, C. Carder, N. Lennard, S.J. Lockey, Marsh, P., Skipp, P., O'Connor, C.D., Goodhead, I., Norbertzcak, H., Harris, B., Ormond, D., Rance, R., Quail, M.A., Parkhill, J., Stephens, R.S. & Clarke, I.N., (2008), Chlamydia trachomatis: genome sequence analysis of Lymphogranuloma Venereum isolates, Genome Res., 18, 161-171 J.N. Williams, P.J. Skipp, H.E. Humphries, M. Christodoulides, C.D. O'Connor, & Heckels, J.E., (2007), Proteomic Analysis of Outer Membranes and Vesicles from Wild-Type Serogroup B Neisseria meningitidis and a Lipopolysaccharide-Deficient Mutant, Infect. Immun., 75, 1364-1372 T.E. Vaughan, P.J. Skipp, C.D. O'Connor, M.J. Hudson, R. Vipond, Elmore, M.J. & Gorringe, A.R., (2006), Proteomic analysis of Neisseria lactamica and Neisseria meningitidis outer membrane vesicle vaccine antigens, Vaccine, 24, 5277-5293 B. Nicholas, P. Skipp, R. Mould, S. Rennard, D. Davies, O'Connor, C.D. & Djukanovic, R., (2006), Shotgun proteomic analysis of human-induced sputum, Proteomics, 6, 4390-4401 P. Skipp, J. Robinson, C.D. O'Connor, I.N. Clarke, (2005), Shotgun proteomic analysis of Chlamydia trachomatis, Proteomics, 5, 1558-1573 R.M. Owens, J.G. Pritchard, P. Skipp, M. Hodey, S.R. Connell, Nierhaus, K.H. & O'Connor, C.D., (2004), A dedicated translation factor controls the synthesis of the global regulator Fis, EMBO J., 23, 3375-3385 A. Best, R.M. La Ragione, W.A. Cooley, C.D. O'Connor, P. Velge, & Woodward, M.J., (2003), Interaction with avian (Div-1) cells and colonisation of specific pathogen free (SPF) chicks by shiga-toxin negative Escherichia coli O157:H7 (NCTC 12900), Vet. Microbiol., 93, 207-222