个人简介

Dr Oscar Ces is a Reader at the Department of Chemistry and is co-chair of the Institute of Chemical Biology, director of the Institute of Chemical Biology Doctoral Training Centre and co-director of the Membrane Biophysics Platform. His expertise lies in soft condensed matter and membrane biophysics, artificial cells, bottom-up synthetic biology, membrane-protein interactions, biomembrane mechanics, drug-membrane interactions, single-cell analysis using microfluidic technologies and biomimetic-microfluidic systems. Since 2006 he has published 40+ papers in these areas, given 20+ invited lectures and secured over £10M current funding. He is also co-founder of the Proxomics Research (£4.6M; 13 academic partners) and £6M CAPITALS research programmes. Most recently he has embarked on a Optonanofluidics initiative with collaborators in Durham which is looking at optical control of emulsion drops for nanofluidics and microfabrication. His research also involves collaborations with industry including GSK plc, Proctor and Gamble and Pfizer plc. See below for further details of these research programmes. He is a member of the Editorial Board of Single Cell Analysis (Associate Editor), the Editorial Advisory Panel for Molecular Membrane Biology and the Chemistry Subcommittee of Imperial College Press. In 2009 he was awarded the inaugural Chemistry Department Lecture SOLE Prize and in 2010 the Rector''''s Award for Excellence in Teaching.

研究领域

Chemical Biology

The CAPITALS Programme is a large-scale collaboration between leading groups at Imperial College London, Durham University, the University of Leeds, the University of Cambridge and the University of Nottingham. The programme brings together the ideal team to work at the forefront of the emerging field of molecular membrane engineering to design and construct new biologically-inspired devices and systems based on lipid bilayer structures. This will revolutionise the design and fabrication of smart, soft materials and in the longer term, will lead to a paradigm shift in areas such as nanomedicine, bioelectronics, biological computing devices and synthetic cells. Single Cell Proteomics Research Group A £5M multidisciplinary initiative funded by the EPSRC to create an advanced suite of technologies for the study of single cells using proteomic approaches. The project includes teams from Imperial College, the Institute of Cancer Research and the London Research Institute of Cancer Research UK. Membrane Biophysics Platform The Membrane Biophysics group, run jointly with Professor Richard Templer, Professor John Seddon and Dr Rob Law, focuses on applying physical chemistry techniques and instrumentation to gain a novel insight into biological and bio-physical properties of natural and model membranes. Proxomics Initiative A £4.6 million multidisciplinary research programme between Imperial College London, University of Glasgow and Aston University that has been funded by the Engineering and Physical Sciences Research Council (EPSRC) to focus on the development of new technologies for understanding the causes of ageing and protein-oxidative damage. Non Specific Binding Initiative Multi-disciplinary project in collaboration with GSK plc aimed at studying the role played by biological membranes in determining the ability of drug molecules to bind specifically. This has led to the discovery of a novel drug translocation mechanism based upon drug-induced membrane degradation

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Barriga HM, Bazin R, Templer RH, et al., 2015, Buffer-Induced Swelling and Vesicle Budding in Binary Lipid Mixtures of Dioleoylphosphatidylcholine:Dioleoylphosphatidylethanolamine and Dioleoylphosphatidylcholine:Lysophosphatidylcholine Using Small-Angle X-ray Scattering and (31)P Static NMR., Langmuir Tyler AII, Barriga HMG, Parsons ES, et al., 2015, Electrostatic swelling of bicontinuous cubic lipid phases, Soft Matter, ISSN:1744-6848 Karamdad K, Law RV, Seddon JM, et al., 2015, Preparation and mechanical characterisation of giant unilamellar vesicles by a microfluidic method, Lab On A Chip, Vol:15, ISSN:1473-0197, Pages:557-562 Bolognesi G, Hargreaves A, Ward AD, et al., 2015, Microfluidic generation of monodisperse ultra-low interfacial tension oil droplets in water, Rsc Advances, Vol:5, ISSN:2046-2069, Pages:8114-8121 Furse S, Mak L, Tate EW, et al., 2015, Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity, Organic & Biomolecular Chemistry, Vol:13, ISSN:1477-0520, Pages:2001-2011