个人简介
Education
PhD Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA (2004-2009)
BSc Microbiology, Sun Yat-Sen (Zhongshan) University, Guangzhou, China (1996-2000)
Academic and Professional Experience
2014-present Assistant Professor, Faculty of Health Sciences,
University of Macau, Macao
2009 – 2014 Postdoctoral Research Fellow, UCSD Stem Cell Program, University of California San Diego, La Jolla, California, USA
Course Outlines
HSCI2000 Cell and Molecular Biology
HSCI4002 Stem Cell Biology and Regenerative Medicine
研究领域
My research focuses on understanding how chromatin-modifying enzymes control cell fate decisions during pancreas development, and elucidating the epigenetic and transcriptional mechanisms that underlie pancreatic lesion. We utilized both mouse genetic approaches and a parallel hESC-based in vitro differentiation system which recapitulates the sequence of events observed during in vivo pancreas development, where pluripotent cells first commit to endoderm, then primitive gut tube, posterior foregut, and subsequently pancreas. Using this differentiation platform, we have begun to dissect the epigenetic events that drive pancreatic development. Additional ongoing research in my laboratory includes:
Using high-throughput sequencing and genome-editing technologies to study the DNA and histone modifications in pancreatic cancer, elucidating the role of chromatin modification enzymes in mouse models, and exploring novel anti-cancer or preventive strategies by targeting key epigenetic pathways.
In vitro differentiation of patient-specific iPS/hES cells as models of pancreatic diseases, such as diabetes mellitus
近期论文
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Representative Publications
Zhang H, Wang Y, Dou J, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie, R, Zhao X, Yu J. Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis. Oncogene. 2018 Oct 10.[Epub ahead of print]
Wu X, Li G, Xie, R. Decoding the role of TET family dioxygenases in lineage specification. Epigenetics & Chromatin. 2018, 11(1):58. Review.
Li J, Wu X, Zhou Y, Lee M, Guo L, Han W, Mo W, Cao WM, Sun D*, Xie, R*, Huang Y*. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC. Nucleic Acids Res. 2018, [Epub ahead of print]. (*co-corresponding author)
Ye J, Yuen SM, Murphy G, Xie, R*, Kwok HF*. Anti-tumor effects of a ‘human & mouse cross-reactive’ anti-ADAM17 antibody in a pancreatic cancer model in vivo. Eur J Pharm Sci. 2017, 110:62-69. (*co-corresponding author)
Niu Y, Li Q, Xie, R, Liu S, Wang R, Xing P, Shi Y, Wang Y, Dong L, Wang C. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material. Biomaterials. 2017, 139:39-55.
Shih, HP; Seymour, PA; Patel, NA; Xie, R; Wang, A; Liu, PP; Yeo, GW; Magnuson, MA; Sander, M. A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells. Cell reports. 2015, 13;13(2):326-36.
Wang, A; Yue, F; Li, Y; Xie, R; Harper, T; Patel, NA; Muth, K; Palmer, J; Qiu, Y; Wang, J; Lam, DK; Raum, JC; Stoffers, DA; Ren, B; Sander M. Epigenetic priming of enhancers predicts developmental competence of hESC-Derived endodermal lineage intermediates. Cell Stem Cell. 2015, 16(4):386-99.
Xie, R; Carrano, AC; Sander, M. A systems view of epigenetic networks regulating pancreas development and β-cell function. Wiley Interdiscip Rev Syst Biol Med. 2015, 7(1):1-11.
Zhang, F*; Xie, R*; Lau, SS; Monks, TJ. PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced non-apoptotic cell death. Toxicol. Sci. 2014, 140(1), 118-34. (*Equal contribution)
Xie, R; Everett, LJ; Lim, HW; Patel, NA; Schug, J; Kroon, E; Kelly, OG; Wang, A; D’Amour, KA; Robins, AJ; Won, KJ; Kaestner, KH; Sander, M. Dynamic chromatin remodeling mediated by Polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 2013, 12(2), 224-237.
van der Meulen, T; Xie, R; Kelly, OG; Vale, WW; Sander, M; Huising, MO. Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLOS One.2012, 7(12), e52181.
Morán, I; Akerman, I; van de Bunt, M; Xie, R; Benazra, M; Nammo, T; Arnes, L; Nakić, N; García-Hurtado, J; Rodríguez-Seguí, S; Pasquali, L; Sauty-Colace, C; Beucher, A; Scharfmann, R; van Arensbergen, J; Johnson, PR; Berry, A; Lee, C; Harkins, T; Gmyr, V; Pattou, F; Kerr-Conte, J; Piemonti, L; Berney, T; Hanley, N; Gloyn, AL; Sussel, L; Langman, L; Brayman, KL; Sander, M; McCarthy, MI; Ravassard, P; Ferrer, J. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metabolism. 2012, 16(4), 435-448.
Seymour, PA; Shih, HP; Patel, NA; Freude, KK; Xie, R; Lim, CJ; Sander, M. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012, 139(18), 3363-72.
Monks, TJ; Xie, R; Tikoo, K; Lau, SS. ROS-induced histone modifications and their role in cell survival and cell death. Drug Metab Rev. 2006, 38(4), 755-767.
Xie, R; Zhuang, M; Ross, LS; Gomez, I; Oltean, DI; Bravo, A; Soberon, M; Gill, SS. Single amino acid mutations in the cadherin receptor from Heliothis virescens affect its toxin binding ability to Cry1A toxins. J Biol Chem. 2005, 280(9), 8416-8425.
Yu, J; Xie, R; Tan, L; Xu, W; Zeng, S; Chen, J; Tang, M; Pang, Y. Expression of the full-length and 3′-spliced cry1Ab gene in the 135-kDa crystal protein minus derivative of Bacillus thuringiensis subsp. kyushuensis. Curr Microbiol. 2002, 45(2), 133-138.
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