高慧玲 - 东北大学 - 生命科学与健康学院

个人简介

高慧玲博士，现任东北大学生命科学与健康学院神经科学研究所副教授。2013年在日本爱媛大学获得博士学位。近年来以第一作者和通讯作者发表SCI收录期刊论文发表SCI收录期刊论文多篇。主持国家自然科学基金及青年基金2项，教育部基本科研业务费2项，并参与多项基金的科研工作。获批发明专利一项。国内工作经历 2013.06-至今东北大学生命科学与健康学院副教授教育经历 2009.09-2014.04 日本爱媛大学医学部解剖学与发生学博士 2004.09-2009.07 中国医科大学组织胚胎学博士 1999.09-2004.07 吉林大学医学部临床医学学士代表性论文一种青霉胺鼻凝胶剂及其制备方法专利号：ZL2016 1 0075591.8高慧玲，郭静文，王占友，王璞

研究领域

研究方向为脑锌代谢与学习记忆以及神经退行性疾病发病机理的研究。应用小鼠和细胞模型，探讨金属离子及其转运体调节脑内金属离子代谢的分子机制。

近期论文

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Xiaoyu Zhang, Manli Zhong, Pu Zhao, Xiancheng Zhang, You Li, Xuliang Wang, Jia Sun, Wang Lan, Hehong Sun, Zhanyou Wang*, Hui-ling Gao*. Screening a specific Zn(ii)-binding peptide for improving the cognitive decline of Alzheimer’s disease in APP/PS1 transgenic mice by inhibiting Zn2+-mediated amyloid protein aggregation and neurotoxicity.Biomater Sci. 2019 Oct 7. doi: 10.1039/c9bm00676a. Hui-ling Gao*, Cheng Li, Hiroaki Nabeka*, Tetsuya Shimokawa, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. An 18-mer Peptide Derived from Prosaposin Ameliorates the Effects of Aβ1-42 Neurotoxicity on Hippocampal Neurogenesis and Memory Deficit in Mice. J Alzheimers Dis. 2016 Jun 30;53(3):1173-92. doi: 10.3233/JAD-160093 Hui-ling Gao, Cheng Li, Hiroaki Nabeka*, Tetsuya Shimokawa, Naoto Kobayashi, Shouichiro Saito, Zhan-You Wang, Ya-ming Cao, and Seiji Matsuda. Decrease in prosaposin in the Dystrophic mdx mouse brain. PLoS One. 2013 Nov 14;8(11):e80032. doi: 10.1371/journal.pone.0080032. eCollection 2013. Hui-Ling Gao, Cheng Li, Nabeka Hiroaki*, Shimokawa Tetsuya, Saito Shouichiro, Zhan-You Wang, Ya-ming Cao, Seiji Matsuda. Attenuation of MPTP/MPP+ toxicity in vivo and in vitro by an 18-mer peptide derived from prosaposin. Neuroscience, doi: 10.1016/j.neuroscience.2013.01.007, 2013. Hui-Ling Gao, He Xu, Na Xin, Wei Zheng, Zhi-Hong Chi, Zhan-You Wang*. Disruption of the CaMKII/CREB signaling is associated with zinc deficiency-induced learning and memory impairments. Neurotoxicity Research, 19(4), 584–591, 2011. Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Zhen-Yu Wang, Jie Chen, Zhan-You Wang*. Zinc deficiency reduces neurogenesis accompanied by neuronal apoptosis through caspase-dependent and -independent signaling pathways. Neurotoxicity Research, 16(4), 416-425, 2009. Hui-Ling Gao, Wan-Yu Feng, He Xu, Liping Huang, Zhan-You Wang*. Golgi apparatus localization of ZNT7 in the mouse cerebellum. Histology and Histopathology, 24(5), 567-572, 2009. Hui-Ling Gao, Xin Wang, Wei Zheng, Annica Dahlstrom, Liping Huang, Zhan-You Wang*. Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic Neuroscience, 140(1-2), 59-65, 2008. Cheng Li, Hui-Ling Gao, Tetsuya Shimokawa*, Hiroaki Nabeka, Fumihiko Hamada, Hiroaki Araki, Ya-ming Cao, Naoto Kobayashi, Seiji Matsuda. Prosaposin expression in the regenerated muscles of mdx and cardiotoxin-treated mice. Histology and Histopathology, in press, 2013 Jan 17. [Epub ahead of print], 2013. He Xu, Hui-Ling Gao, Wei Zheng, Na Xin, Zhi-Hong Chi, Shu-Ling Bai, Zhan-You Wang*. Lactational zinc deficiency-induced hippocampal neuronal apoptosis by a BDNF-independent TrkB signaling pathway. Hippocampus, 21(5), 495-501, 2011. Tian-Shu Sun,Xiao Ju,Hui-Ling Gao,Tao Wang,Dennis J. Thiele,Jia-Yi Li, Zhan-You Wang, Chen Ding. Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis. Nat Commun. 2014 Nov 24;5:5550. doi: 10.1038/ncomms6550. Bing Xue, Jie Chen*, Hui-ling Gao, Shouichiro Saito, Naoto Kobayashi, Tetsuya Shimokawa, Hiroaki Nabeka, Akira Sano, Seiji Matsuda. Chronological changes in prosaposin in the developing rat brain. Neuroscience Research, 71(1), 22-34, 2011. Xue-Jiao Zhang, Cheng Li,Hui-ling Gao, Hiroaki Nabeka, Tetsuya Shimokawa, Hiroyuki Wakisaka, Seiji Matsuda, Naoto Kobayashi*. Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity. Cell Molecular Biology Letter, 16(2), 279-295, 2011. Zhi-Hong Chi, Wan-Yu Feng, Hui-Ling Gao, Wei Zheng, Liping Huang, Zhan-You Wang*. ZnT7 and Zn2+ are present in different cell populations in the mouse testis. Histology and Histopathology, 24(1), 25-30, 2009.